Maternal magnesium intake and childhood wheezing in offspring at 3 years of age: the Japan Environment and Children's Study
Murata T, Kyozuka H, Fukuda T, Imaizumi K, Isogami H, Yasuda S, Yamaguchi A, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K, Japan Environment and Children’s Study (JECS) Group
The British journal of nutrition · 0 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Child Health and Development
- Universidad u hospital
- University of Occupational and Environmental Health
- Universidad u hospital
- Hyogo College of Medicine
- Universidad u hospital
- Hokkaido University
- Universidad u hospital
- Chiba University
- Universidad u hospital
- Nagoya City University
Según 6 financiadores declarados.
Publicación
- Publicado
- 2023-05-26 · Br J Nutr · vol. 130 · número 11 · págs. 1973–1981
- Editorial
- Cambridge University Press
- Citado
- 2 citas · más que el 78% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Birth, Development, and Health · Neonatal Respiratory Health Research · Pregnancy and preeclampsia studies
- Palabras clave
- Offspring, Medicine, Incidence (geometry), Pregnancy, Confounding, Logistic regression, Pediatrics, Demography, Internal medicine, Biology
- MeSH
- humans, prenatal exposure delayed effects, respiratory sounds, magnesium, diet, incidence, pregnancy, adult, child, preschool, japan, female, male, maternal nutritional physiological phenomena
16 autores
- Tsuyoshi Murata🇯🇵 · autor de correspondenciaFukushima Medical University; Fukushima Prefectural Culture Center
- Hyo Kyozuka🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Toma Fukuda🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Karin Imaizumi🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Hirotaka Isogami🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Shun Yasuda🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Akiko Yamaguchi🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Akiko Satô🇯🇵Fukushima Prefectural Culture Center
- Yuka Ogata🇯🇵Fukushima Prefectural Culture Center
- Kosei Shinoki🇯🇵Fukushima Prefectural Culture Center
- Mitsuaki Hosoya🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Seiji Yasumura🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Koichi Hashimoto🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Hidekazu Nishigori🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- Keiya Fujimori🇯🇵Fukushima Medical University; Fukushima Prefectural Culture Center
- The Japan Environment and Children’s Study (JECS) Group
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study evaluated the association between maternal magnesium intake (MMI) and childhood wheezing incidence in 3-year-old offspring. We hypothesised that higher MMI imparts anti-inflammatory and antioxidant effects that decrease childhood wheezing incidence in offspring. Data of 79 907 women (singleton pregnancy, ≥ 22 weeks) from the Japan Environment and Children's Study (enrolled between 2011 and 2014) were analysed. Participants were categorised into quintiles of MMI (< 148·00, 148·00-187·99, 188·00-228·99, 229·00-289·99 and ≥ 290·00 mg/d), quintiles of adjusted MMI for daily energy intake (aMMI) (< 0·107, 0·107-0·119, 0·120-0·132, 0·133-0·149 and ≥ 0·150 mg/kcal) and MMI levels either below or above the ideal value (< 310·00 or ≥ 310·00 mg/d). Multivariable logistic regression analysis was performed to calculate OR for the incidence of childhood wheezing in offspring among participants in each MMI category, with the lowest MMI group considered the reference group. Maternal demographic, socio-economic, medical and other nutrient intake backgrounds were considered potential confounding factors. The adjusted OR (aOR) for childhood wheezing in the offspring of women with the highest MMI was 1·09 (95 % CI, 1·00, 1·20), whereas that calculated based on aMMI categories and offspring of women with above-ideal MMI levels remained unchanged. The highest MMI was associated with slightly increased childhood wheezing incidence in the offspring. MMI during pregnancy had an insignificant clinical impact on this incidence; moreover, modifying MMI would not significantly improve childhood wheezing incidence in offspring. Therefore, further studies should clarify the association between other prenatal factors and childhood wheezing incidence in offspring.
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