The Replacement of Only One Portion of Starchy Carbohydrates with Green Leafy Vegetables Regresses Mid and Advanced Stages of NAFLD: Results from a Prospective Pilot Study
De Nucci S, Rinaldi R, Di Chito M, Donghia R, Giannuzzi V, Shahini E, Cozzolongo R, Pesole PL, Coletta S, De Pergola G, Giannelli G
Nutrients · 9 citas
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Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Italian Ministry of Health with Ricerca Corrente 2021
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-05-12 · Nutrients · vol. 15 · número 10 · pág. 2289
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 8 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Nutritional Studies and Diet
- Palabras clave
- Leafy vegetables, Food science, Medicine, Leafy, Biotechnology, Environmental health, Biology, Botany
- MeSH
- humans, vegetables, starch, prospective studies, pilot projects, middle aged, female, male, non-alcoholic fatty liver disease
11 autores
- Sara De Nucci🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Roberta Rinaldi🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Martina Di Chito🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Rossella Donghia🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Vito Giannuzzi🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Endrit Shahini🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Raffaele Cozzolongo🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Pasqua Letizia Pesole🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Sergio Coletta🇮🇹Gastroenterology Hospital "Saverio de Bellis"
- Giovanni De Pergola🇮🇹 · autor de correspondenciaGastroenterology Hospital "Saverio de Bellis"
- Gianluigi Giannelli🇮🇹Gastroenterology Hospital "Saverio de Bellis"
Resumen
El texto original del estudio, en el idioma en que se publicó.
The gold standard treatment for NAFLD is weight loss and lifestyle interventions, which require a diet enriched in fiber and reduced in sugars and saturated fats. Fibres may be advantageous for NAFLD patients since they reduce and slow the absorption of carbohydrates, lipids, and proteins, lowering the energy density of the meal and increasing their sense of satiety. Furthermore, the polyphenol content and other bioactive compounds of vegetables have antioxidant and anti-inflammatory properties preventing disease progression. The aim of this study is to ascertain the effects of a diet enriched by green leafy vegetables and with a moderate restriction of carbohydrate intake in patients with NAFLD over a three month period. Among the forty patients screened, twenty four patients completed the clinical trial consisting of swapping one portion of carbohydrate-rich food for one portion of green leafy vegetables, and liver and metabolic markers of NAFLD were evaluated. All patients underwent routine blood tests, anthropometric measurements, bioelectrical impedance analysis, fibroscan, and fatty liver index (FLI) evaluation before and at the end of the study. The population under study (n = 24) had a median age of 47.5 (41.5-52.5) years and included mainly women (70.8%). We found that FLI, which is used to predict fatty liver (73 (33-89) vs. 85 (54-95), p p = 0.007), were both improved after changes in diet. The BMI (33.3 (28.6-37.3) vs. 35.3 (31.2-39.0), p p p p p = 0.03) were also all significantly lower after three months of diet. Metabolic parameters linked to NAFLD decreased: HbA1c (36.0 (33.5-39.0) vs. 38.0 (34.0-40.5), p = 0.01), triglycerides (72 (62-90) vs. 90 (64-132), p = 0.03), and the liver markers AST (17 (14-19) vs. 18 (15-27), p = 0.01) and γGT (16 (13-20) vs. 16 (14-27), p = 0.02). In conclusion, replacing only one portion of starchy carbohydrates with one portion of vegetables for a three month period is sufficient to regress, at least in part, both mid and advanced stages of NAFLD. This moderate adjustment of lifestyle habits is easily achievable.
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