Financiado en parte por Novo Nordisk
Effectiveness of intermittent fasting for weight loss in individuals with obesity: A meta-analysis of randomized controlled trials
Silverii GA, Cresci B, Benvenuti F, Santagiuliana F, Rotella F, Mannucci E
Nutrition, metabolism, and cardiovascular diseases : NMCD · 23 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Novo Nordisk
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-05-10 · Nutr Metab Cardiovasc Dis · vol. 33 · número 8 · págs. 1481–1489
- Editorial
- Elsevier BV
- Citado
- 34 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Obesity, Physical Activity, Diet
- Palabras clave
- intermittent fasting, obesity, weight loss, alternate-day fasting, time-restricted eating, LDL cholesterol, fasting blood glucose, blood pressure, metabolic parameters, body mass index, psychological well-being
- MeSH
- humans, obesity, weight loss, fasting, cholesterol, hdl, randomized controlled trials as topic
6 autores
- Giovanni Antonio Silverii🇮🇹 · autor de correspondenciaUniversity of Florence
- Barbara Cresci🇮🇹Azienda Ospedaliero-Universitaria Careggi
- Federica Benvenuti🇮🇹Azienda Ospedaliero-Universitaria Careggi
- Federica Santagiuliana🇮🇹Azienda Ospedaliero-Universitaria Careggi
- Francesco Rotella🇮🇹Azienda Ospedaliero-Universitaria Careggi
- Edoardo Mannucci🇮🇹University of Florence
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
To assess whether intermittent fasting (IF) diets are associated with improvement in weight loss, metabolic parameters, and subjective well-being, in people with obesity.
Data synthesis
We performed a Meta-analysis of Randomized Controlled Trials longer than 2 months, retrieved through an extensive search on MedLine, Cochrane CENTRAL Library, and Embase online databases, comparing weight loss with IF diets and control diets in people with Body Mass index (BMI) > 30 kg/m2. We retrieved 9 trials, enrolling 540 patients. IF was not associated with a significantly greater reduction of body weight or BMI at any time point with respect to controls or in respect to continuous restricted diets, with low-to moderate quality of evidence; no significant difference in efficacy between alternate day fasting and time restricted eating was found. Differences in fasting plasma glucose, total or high-density lipoprotein cholesterol or blood pressure at any time point were not statistically significant, whereas a reduction of low-density lipoprotein cholesterol (MD -8.39 [-15.96, -0.81] mg/dl, P = 0.03; I2 = 0%) was observed at 2-4 months, but not in the longer term. Data on psychological parameters and overall well-being were insufficient to perform a formal meta-analysis, whereas a qualitative synthesis did not show any difference between IF and controls.
Conclusions
IF is not associated with greater or lesser weight loss than non-intermittent fasting diets. Further data on psychological parameters and overall well-being are needed to properly assess the role of IF diets in the management of obesity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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