Financiado en parte por Almond Board of California
The effects of long-term almond consumption on whole-body insulin sensitivity, postprandial glucose responses, and 48 h continuous glucose concentrations in males and females with prediabetes: a randomized controlled trial
Gravesteijn E, Mensink RP, Plat J
European journal of nutrition · 10 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-05-31 · Eur J Nutr · vol. 62 · número 6 · págs. 2661–2672
- Editorial
- Springer Science+Business Media
- Citado
- 15 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Diet, Metabolism, and Disease · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- almond consumption, prediabetes, insulin sensitivity, postprandial blood glucose, continuous glucose monitoring, hyperinsulinemic-euglycemic clamp, overweight and obesity, weight gain, energy intake, type 2 diabetes prevention, nuts, sex differences
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, insulin resistance, insulin, glucose, blood glucose, cross-over studies, postprandial period, female, male, prunus dulcis
3 autores
- Elske Gravesteijn🇳🇱Maastricht University Medical Centre; Maastricht University
- Ronald P. Mensink🇳🇱Maastricht University Medical Centre; Maastricht University
- Jogchum Plat🇳🇱 · autor de correspondenciaMaastricht University Medical Centre; Maastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Findings concerning the effects of almond consumption on glucose metabolism are inconsistent which might relate to body weight gain. The effects of long-term almond consumption on glucose metabolism are investigated in a free-living setting without detailed dietary instructions in males and females with overweight/obesity and prediabetes.
Methods
Forty-three participants volunteered in this randomized, cross-over trial with a 5-months control and intervention period and a 2-months wash-out. In the intervention period participants daily consumed 50 g whole almonds. At the end of both periods insulin sensitivity was assessed by a hyperinsulinemic euglycemic clamp, and postprandial glucose responses, and 48 h continuous glucose concentrations were measured.
Results
Almond consumption significantly decreased insulin sensitivity (P = 0.002), and increased postprandial glucose concentrations (P = 0.019), as well as fasting insulin concentrations (P = 0.003) as compared to the control period. The AUCs for 24 h glucose concentrations were not significantly different between control and intervention (P = 0.066). Almond consumption also significantly increased BMI (P = 0.002), and waist circumference (P = 0.013), supported by the concurrent increased energy intake (P = 0.031). The effects on glucose metabolism could only partly be explained by the observed weight gain as the almond effect remained after correcting for BMI changes.
Conclusions
In participants with prediabetes, long-term almond consumption showed adverse effects on insulin sensitivity and glucose metabolism. As almonds seemed not to have fully replaced other food items, it might be necessary to provide more supporting guidelines on how to incorporate energy-dense nuts into healthy diets to prevent type 2 diabetes development.
Clinical trial registration
This clinical trial was registered in February 2018 as NCT03419702.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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