Effects of mixed nut consumption on LDL cholesterol, lipoprotein(a), and other cardiometabolic risk factors in overweight and obese adults
Nora CL, Zhang L, Castro RJ, Marx A, Carman HB, Lum T, Tsimikas S, Hong MY
Nutrition, metabolism, and cardiovascular diseases : NMCD · 9 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Organización sin fines de lucro
- American Heart Association-American Stroke Association
- Subvenciones
- American Heart Association (16GRNT31360007)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-05-15 · Nutr Metab Cardiovasc Dis · vol. 33 · número 8 · págs. 1529–1538
- Editorial
- Elsevier BV
- Citado
- 13 citas · más que el 78% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Lipoproteins and Cardiovascular Health
- Palabras clave
- Overweight, Adiponectin, Medicine, Obesity, Internal medicine, Macadamia nut, Nut, Lipoprotein, Cholesterol, Endocrinology, Food science, Insulin resistance, Chemistry
- MeSH
- humans, nuts, obesity, inflammation, lipoprotein(a), risk factors, adult, overweight, adiponectin, cholesterol, ldl, 8-hydroxy-2'-deoxyguanosine, cardiometabolic risk factors
8 autores
- Chelsea L. Nora🇺🇸San Diego State University
- Liyue Zhang🇺🇸San Diego State University
- Robert J. Castro🇺🇸San Diego State University
- Amanda Marx🇺🇸San Diego State University
- Hannah B. Carman🇺🇸San Diego State University
- Tiffany Lum🇺🇸San Diego State University
- Sotirios Tsimikas🇺🇸University of California San Diego
- Mee Young Hong🇺🇸 · autor de correspondenciaSan Diego State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Elevated LDL-C, lipoprotein(a) [Lp(a)], and inflammation are associated with greater risk for atherosclerotic cardiovascular events. Consumption of individual nut types decreases these risk factors but knowledge about the effect of mixed nuts on Lp(a) is limited. The objective of this study was to determine the effects of consuming 42.5 g/day of mixed nuts on LDL-C, Lp(a), and inflammatory markers in individuals with overweight or obesity.
Methods and results
In a 16-week randomized control trial, 29 participants with overweight or obesity (BMI 25-40 kg/m2) consumed either 42.5 g/day of mixed nuts (cashews, almonds, macadamia nuts, Brazil nuts, pecans, pistachios, walnuts, and peanuts) or 69 g/day isocaloric pretzels. Blood samples were collected at baseline, week 8, and week 16 for analysis on total cholesterol (TC), LDL-C, Lp(a), inflammation markers, glucose, insulin, adiponectin and liver function enzymes. No significant differences were seen in TC, LDL-C, HDL-C, Lp(a), or liver function enzymes between the two groups. Participants consuming mixed nuts had significantly lower body fat percentage and diastolic blood pressure, and higher adiponectin (all P ≤ 0.05). C-reactive protein (CRP) and 8-oxo-deoxyguanosis (8-oxodG) showed non-significant decreasing trends and total antioxidant capacity (TAC) had a non-significant increasing trend in the mixed nut group.
Conclusion
Consumption of mixed nuts had no evidence of an effect on LDL-C or Lp(a) throughout the intervention. Notably, mixed nut consumption lowered body fat percentage without significant changes in body weight or BMI. Future studies with larger sample sizes investigating the changing trends of CRP, 8-oxodG, and TAC are warranted.
Clinical trial register
NCT03375866.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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