Reduction in blood pressure following acute dietary nitrate ingestion is correlated with increased red blood cell S-nitrosothiol concentrations
Wei C, Vanhatalo A, Kadach S, Stoyanov Z, Abu-Alghayth M, Black MI, Smallwood MJ, Rajaram R, Winyard PG, Jones AM
Nitric oxide : biology and chemistry · 14 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Exeter
- Gobierno
- China Scholarship Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-05-31 · Nitric Oxide · vol. 138-139 · págs. 1–9
- Editorial
- Elsevier BV
- Citado
- 16 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 87 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Renal function and acid-base balance · Heart Rate Variability and Autonomic Control
- Palabras clave
- Ingestion, Nitrate, Blood pressure, Reduction (mathematics), Medicine, Internal medicine, Chemistry, Mathematics
- MeSH
- erythrocytes, humans, beta vulgaris, hypotension, nitrates, nitrites, nitric oxide, nitrogen dioxide, s-nitrosothiols, double-blind method, blood pressure, eating, dietary supplements
10 autores
- Chenguang Wei🇬🇧University of Exeter
- Anni Vanhatalo🇬🇧University of Exeter
- Stefan Kadach🇬🇧University of Exeter
- Zdravko Stoyanov🇬🇧University of Exeter
- Mohammed Haidar Abu-Alghayth🇸🇦University of Bisha
- Matthew I. Black🇬🇧University of Exeter
- Miranda J. Smallwood🇬🇧University of Exeter
- Raghini Rajaram🇬🇧University of Exeter
- Paul Graham Winyard🇬🇧University of Exeter
- ANDREW MARK JONES🇬🇧 · autor de correspondenciaUniversity of Exeter
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO3-) supplementation can enhance nitric oxide (NO) bioavailability and lower blood pressure (BP) in humans. The nitrite concentration ([NO2-]) in the plasma is the most commonly used biomarker of increased NO availability. However, it is unknown to what extent changes in other NO congeners, such as S-nitrosothiols (RSNOs), and in other blood components, such as red blood cells (RBC), also contribute to the BP lowering effects of dietary NO3-. We investigated the correlations between changes in NO biomarkers in different blood compartments and changes in BP variables following acute NO3- ingestion. Resting BP was measured and blood samples were collected at baseline, and at 1, 2, 3, 4 and 24 h following acute beetroot juice (∼12.8 mmol NO3-, ∼11 mg NO3-/kg) ingestion in 20 healthy volunteers. Spearman rank correlation coefficients were determined between the peak individual increases in NO biomarkers (NO3-, NO2-, RSNOs) in plasma, RBC and whole blood, and corresponding decreases in resting BP variables. No significant correlation was observed between increased plasma [NO2-] and reduced BP, but increased RBC [NO2-] was correlated with decreased systolic BP (rs = -0.50, P = 0.03). Notably, increased RBC [RSNOs] was significantly correlated with decreases in systolic (rs = -0.68, P = 0.001), diastolic (rs = -0.59, P = 0.008) and mean arterial pressure (rs = -0.64, P = 0.003). Fisher's z transformation indicated no difference in the strength of the correlations between increases in RBC [NO2-] or [RSNOs] and decreased systolic blood pressure. In conclusion, increased RBC [RSNOs] may be an important mediator of the reduction in resting BP observed following dietary NO3- supplementation.
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