Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial
Hodges JK, Maiz M, Cao S, Lachcik PJ, Peacock M, McCabe GP, McCabe LD, Cladis DP, Jackson GS, Ferruzzi MG, Lila MA, Bailey RL, Martin BR, Weaver CM
The American journal of clinical nutrition · 13 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCCIH NIH HHS
- Subvenciones
- National Center for Research Resources (UL1TR001108); National Center for Complementary and Integrative Health (R01AT008754); National Center for Advancing Translational Sciences (UL1TR-001108); National Institutes of Health (UL-1-TR001108)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-06-01 · Am J Clin Nutr · vol. 118 · número 2 · págs. 382–390
- Editorial
- Elsevier BV
- Citado
- 16 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Bone health and osteoporosis research · Phytochemicals and Antioxidant Activities · Bone Metabolism and Diseases
- Palabras clave
- postmenopausal women, bone loss, ovariectomy, dose-response relationship, bone resorption markers, hippuric acid, 25-hydroxyvitamin D, bone health, dietary intervention, osteoporosis prevention, freeze-dried fruit powder
- MeSH
- animals, humans, rats, osteoporosis, postmenopausal, bone resorption, calcium, powders, cross-over studies, postmenopause, female, biomarkers, blueberry plants
14 autores
- Joanna K. Hodges🇺🇸Pennsylvania State University
- María Maiz🇺🇸Purdue University West Lafayette
- Sisi Cao🇺🇸San Diego State University
- Pamela J. Lachcik🇺🇸Purdue University West Lafayette
- Munro Peacock🇺🇸Indiana University Indianapolis; Indiana University School of Medicine
- George P. McCabe🇺🇸Purdue University West Lafayette
- Linda Doyle McCabe🇺🇸Purdue University West Lafayette
- Dennis P. Cladis🇺🇸Virginia Tech
- George S. Jackson🇺🇸Purdue University West Lafayette
- Mário G. Ferruzzi🇺🇸Arkansas Children's Nutrition Center; University of Arkansas for Medical Sciences
- Mary Ann Lila🇺🇸North Carolina State University
- Regan Lucas Bailey🇺🇸Texas A&M University
- Berdine R. Martin🇺🇸Purdue University West Lafayette
- Connie M. Weaver🇺🇸 · autor de correspondenciaSan Diego State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Preclinical studies suggest that blueberry consumption is associated with improved bone health.
Objectives
We conducted a blueberry dose-response study in ovariectomized (OVX)-rats that informed a study in postmenopausal women using the urinary appearance of calcium (Ca) tracers from prelabeled bone to reflect changes in bone balance. We hypothesized that blueberry consumption would reduce bone loss in a dose-dependent manner compared with no treatment.
Methods
OVX rats were fed 4 doses of blueberry powder (2.5%, 5%, 10%, and 15%) in randomized order to determine bone 45Ca retention. Fourteen healthy, nonosteoporotic women ≥4 y past menopause were dosed with 50 nCi of 41Ca, a long-lived radioisotope, and equilibrated for 5 mo to allow 41Ca deposition in bone. Following a 6-wk baseline period, participants were assigned to a random sequence of 3 6-wk interventions, a low (17.5 g/d), medium (35 g/d), or high (70 g/d) dose of freeze-dried blueberry powder equivalent to 0.75, 1.5, or 3 cups of fresh blueberries incorporated into food and beverage products. Urinary 41Ca:Ca ratio was measured by accelerator mass spectrometry. Serum bone resorption biomarkers and urinary polyphenols were measured at the end of each control and intervention period. Data were analyzed using a linear mixed model and repeated measures analysis of variance.
Results
In both OVX rats and postmenopausal women, blueberry interventions benefited net bone calcium balance at lower but not at higher doses. In women, net bone calcium retention increased by 6% with the low (95% CI: 2.50, 8.60; P < 0.01) and 4% with the medium (95% CI: 0.96, 7.90; P < 0.05) dose compared with no treatment. Urinary excretion of hippuric acid increased dose-dependently with blueberry consumption. No significant relationships were found between bone resorption biomarkers, 25-hydroxyvitamin D, and interventions.
Conclusions
Moderate consumption (<1 cup/d) of blueberries may be an effective strategy to attenuate bone loss in healthy postmenopausal women. This trial was registered at clinicaltrials.gov as NCT02630797.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.