Financiado en parte por International Nut and Dried Fruit Council
Longer-term mixed nut consumption improves brain vascular function and memory: A randomized, controlled crossover trial in older adults
Nijssen KMR, Mensink RP, Plat J, Joris PJ
Clinical nutrition (Edinburgh, Scotland) · 25 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- International Nut and Dried Fruit Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-06-03 · Clin Nutr · vol. 42 · número 7 · págs. 1067–1075
- Editorial
- Elsevier BV
- Citado
- 35 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Botany, Ecology, and Taxonomy Studies · Ginger and Zingiberaceae research
- Palabras clave
- Medicine, Crossover study, Cerebral blood flow, Arterial stiffness, Randomized controlled trial, Frontal lobe, Internal medicine, Cardiology, Cognitive decline, Placebo, Dementia, Pathology, Blood pressure
- MeSH
- carotid arteries, brain, humans, nuts, cross-over studies, aged, middle aged, pulse wave analysis
4 autores
- Kevin M.R. Nijssen🇳🇱 · autor de correspondenciaMaastricht University Medical Centre; Maastricht University
- Ronald P. Mensink🇳🇱Maastricht University
- Jogchum Plat🇳🇱Maastricht University
- Peter J. Joris🇳🇱Maastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nut consumption may reduce age-related cognitive decline, but underlying mechanisms are unclear.
Objective
To investigate in older adults longer-term effects of mixed nut consumption on brain vascular function, which may underlie improvements in cognitive performance.
Methods
Twenty-eight healthy individuals (age [mean ± SD]: 65 ± 3 years; BMI: 27.9 ± 2.3 kg/m2) were included in a randomized, single-blinded, cross-over trial with a 16-week intervention (60 g/d mixed nuts: walnuts, pistachio, cashew, and hazelnuts) and control period (no nuts), separated by 8 weeks of washout. Participants followed the Dutch food-based dietary guidelines. At the end of each period, cerebral blood flow (CBF), a marker of brain vascular function, was quantified using arterial spin labeling magnetic resonance imaging. Effects on endothelial function, arterial stiffness, and the retinal microvasculature were also assessed. Cognitive performance was measured using the Cambridge Neuropsychological Test Automated Battery.
Results
Body weight remained stable during the study. As compared to the control period, the mixed nut intervention resulted in a higher regional CBF in the right frontal and parietal lobes (treatment effect: 5.0 ± 6.5 mL/100 g/min; P < 0.001), left frontal lobe (5.4 ± 7.1 mL/100 g/min; P < 0.001), and bilateral prefrontal cortex (5.6 ± 6.6 mL/100 g/min; P < 0.001). Carotid artery reactivity (0.7 PP; 95%CI: 0.2 to 1.2; P = 0.007), brachial flow-mediated vasodilation (1.6 PP; 95%CI: 1.0 to 2.2; P < 0.001) and retinal arteriolar calibers were higher (2 μm; 95%CI: 0 to 3; P = 0.037), and carotid-to-femoral pulse wave velocity lower (-0.6 m/s; 95%CI: -1.1 to -0.1; P = 0.032). Further, visuospatial memory (-4 errors [16%]; 95%CI: -8 to 0; P = 0.045) and verbal memory (+1 correct [16%]; 0 to 2; P = 0.035) improved, but executive function and psychomotor speed did not change.
Conclusions
Longer-term mixed nut consumption as part of a healthy diet beneficially affected brain vascular function, which may relate to the observed beneficial effects on memory in older adults. Moreover, different characteristics of the peripheral vascular tree also improved.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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