Magnetic resonance study of visceral, subcutaneous, liver and pancreas fat changes after 12 weeks intermittent fasting in obese participants with prediabetes
Dokpuang D, Zhiyong Yang J, Nemati R, He K, Plank LD, Murphy R, Lu J
Diabetes research and clinical practice · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Maurice Wilkins Centre for Molecular Biodiscovery
- Gobierno
- Health Research Council of New Zealand
- Subvenciones
- Maurice Wilkins Centre for Molecular Biodiscovery (2705733/13294-MWC327); Health Research Council of New Zealand (16/481)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-06-12 · Diabetes Res Clin Pract · vol. 202 · pág. 110775
- Editorial
- Elsevier BV
- Citado
- 10 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- intermittent fasting, prediabetes, obesity, visceral fat, subcutaneous adipose tissue, liver fat, pancreatic fat, probiotic supplementation, weight loss, HbA1c, sex differences, ethnicity
- MeSH
- liver, pancreas, humans, prediabetic state, obesity, weight loss, magnetic resonance imaging, magnetic resonance spectroscopy, subcutaneous fat, intra-abdominal fat, glycated hemoglobin, intermittent fasting
7 autores
- Dech Dokpuang🇹🇭University of Phayao
- John Zhiyong Yang🇳🇿University of Auckland
- Reza Nemati🇳🇿Canterbury Health Laboratories; Canterbury District Health Board
- Kevin He🇺🇸University of Pennsylvania
- Lindsay Dudley Plank🇳🇿University of Auckland
- Rinki Murphy🇳🇿 · autor de correspondenciaUniversity of Auckland; Maurice Wilkins Centre; Health New Zealand
- Jun Lu🇨🇳🇳🇿 · autor de correspondenciaNanchang University; University of Auckland; Maurice Wilkins Centre; Zhejiang University of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
It is not clear whether there are differences in proportions of fat loss from visceral:subcutaneous depots by probiotic supplementation, ethnicity or sex during weight loss; or whether visceral/pancreatic fat depot changes are related to changes in HbA1c. Our objective is to investigate whether weight loss from different fat depots is related to these factors during weight loss achieved by intermittent fasting.
Method
Prediabetes participants on 5:2 intermittent fasting were randomized 1:1 to either daily probiotic or placebo for 12 weeks. Twenty-four patients had magnetic resonance imaging data at baseline and 12 weeks.
Results
After 12 weeks of intermittent fasting, subcutaneous fat (%) changed from 35.9 ± 3.1 to 34.4 ± 3.2, visceral fat (%) from 15.8 ± 1.3 to 14.8 ± 1.2, liver fat (%) from 8.7 ± 0.8 to 7.5 ± 0.7 and pancreatic fat (%) from 7.7 ± 0.5 to 6.5 ± 0.5 (all p < 0.001). Changes in weight, HbA1c, SAT, VAT, LF and PF did not differ significantly between probiotic and placebo groups.
Conclusion
Overall weight loss was correlated with fat loss from subcutaneous depots. Losses from different fat depots did not correlate with changes in HbA1c or differ by probiotic supplementation, ethnicity or sex.
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