Acute kidney injury biomarkers and hydration assessments following prolonged mild hypohydration in healthy young adults
Chapman CL, Holt SM, O'Connell CT, Brazelton SC, Howells WAB, Medved HN, Reed EL, Needham KW, Halliwill JR, Minson CT
American journal of physiology. Renal physiology · 20 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Oregon
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NHLBI NIH HHS
- Gobierno
- HHS | NIH | National Heart, Lung, and Blood Institute
- Gobierno
- NICHD NIH HHS
- Gobierno
- HHS | National Institutes of Health
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL144128); National Heart, Lung, and Blood Institute (F32 HL164021); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R25HD070817); National Institutes of Health (R25HD070817)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2023-06-15 · Am J Physiol Renal Physiol · vol. 325 · número 2 · págs. F199–F213
- Editorial
- American Physical Society
- Citado
- 23 citas · más que el 93% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Thermoregulation and physiological responses · Climate Change and Health Impacts · Electrolyte and hormonal disorders
- Palabras clave
- Acute kidney injury, Medicine, Biomarker, Urinary system, Urine, Food and drug administration, Internal medicine, Kidney, Drug, Urology, Intensive care medicine, Pharmacology, Biology, Biochemistry
- MeSH
- kidney, humans, somatomedins, insulin-like growth factor binding proteins, tissue inhibitor of metalloproteinase-2, female, male, young adult, acute kidney injury, biomarkers
10 autores
- Christopher L. Chapman🇺🇸University of Oregon
- Sadie M. Holt🇺🇸University of Oregon
- Cameron T. O’Connell🇺🇸University of Oregon
- Shaun C. Brazelton🇺🇸University of Oregon
- William A. B. Howells🇺🇸University of Oregon
- Hannah N. Medved🇺🇸University of Oregon
- Emma L. Reed🇺🇸University of Oregon
- Karen Wiedenfeld Needham🇺🇸University of Oregon
- John R. Halliwill🇺🇸University of Oregon
- Christopher Todd Minson🇺🇸 · autor de correspondenciaUniversity of Oregon
Resumen
El texto original del estudio, en el idioma en que se publicó.
The high prevalence of inadequate hydration (e.g., hypohydration and underhydration) is concerning given that extreme heat increases excess hospitalizations for fluid/electrolyte disorders and acute kidney injury (AKI). Inadequate hydration may also be related to renal and cardiometabolic disease development. This study tested the hypothesis that prolonged mild hypohydration increases the urinary AKI biomarker product of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2 ([IGFBP7·TIMP-2]) compared with euhydration. In addition, we determined the diagnostic accuracy and optimal cutoffs of hydration assessments for discriminating positive AKI risk ([IGFBP·TIMP-2] >0.3 (ng/mL)2/1,000). In a block-randomized crossover design, 22 healthy young adults (11 females and 11 males) completed 24 h of fluid deprivation (hypohydrated group) or 24 h of normal fluid consumption (euhydrated group) separated by ≥72 h. Urinary [IGFBP7·TIMP-2] and other AKI biomarkers were measured following the 24-h protocols. Diagnostic accuracy was assessed via receiver operating characteristic curve analysis. Urinary [IGFBP7·TIMP-2] [1.9 (95% confidence interval: 1.0-2.8) vs. 0.2 (95% confidence interval: 0.1-0.3) (ng/mL)2/1,000, P = 0.0011] was markedly increased in hypohydrated versus euhydrated groups. Urine osmolality (area under the curve: 0.91, P P 2O and 1.025 arbitrary units. In conclusion, prolonged mild hypohydration increased urinary [IGFBP7·TIMP-2] in males and females. Urinary [IGFBP7·TIMP-2] corrected to urine concentration was elevated in males only. Urine osmolality and urine specific gravity may have clinical utility for discriminating positive AKI risk following prolonged mild hypohydration.NEW & NOTEWORTHY This study found that prolonged mild hypohydration in healthy young adults increased the Food and Drug Administration approved acute kidney injury (AKI) biomarker urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2 [IGFBP7·TIMP-2]. Urine osmolality and specific gravity demonstrated an excellent ability to discriminate positive AKI risk. These findings emphasize the importance of hydration in protecting renal health and lend early support for hydration assessment as an accessible tool to assess AKI risk.
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