Habitual dietary nitrate intake and cognition in the Australian Imaging, Biomarkers and Lifestyle Study of ageing: A prospective cohort study
Rajendra A, Bondonno NP, Murray K, Zhong L, Rainey-Smith SR, Gardener SL, Blekkenhorst LC, Ames D, Maruff P, Martins RN, Hodgson JM, Bondonno CP, AIBL Research Group
Clinical nutrition (Edinburgh, Scotland) · 15 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Grupo de la industria
- Science and Industry Endowment Fund
- Organización sin fines de lucro
- National Heart Foundation of Australia
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-06-05 · Clin Nutr · vol. 42 · número 8 · págs. 1251–1259
- Editorial
- Elsevier BV
- Citado
- 16 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 78 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Medicine, Nitrate, Cognition, Ageing, Cognitive decline, Neuropsychology, Gerontology, Environmental health, Internal medicine, Dementia, Ecology, Disease, Biology, Psychiatry
- MeSH
- brain, nitrates, prospective studies, cognition, neuropsychological tests, genotype, australia, apolipoprotein e4
12 autores
- Anjana Rajendra🇦🇺Edith Cowan University
- Nicola P. Bondonno🇦🇺🇩🇰Edith Cowan University; Danish Cancer Society
- Kevin J. Murray🇦🇺The University of Western Australia
- Liezhou Zhong🇦🇺Edith Cowan University
- Stephanie R. Rainey‐Smith🇦🇺Edith Cowan University; Murdoch University; The University of Western Australia; Australian Alzheimer’s Research Foundation
- Samantha L. Gardener🇦🇺Edith Cowan University; Murdoch University; Australian Alzheimer’s Research Foundation
- Lauren C. Blekkenhorst🇦🇺Edith Cowan University
- David Ames🇦🇺The Royal Melbourne Hospital; The University of Melbourne; National Ageing Research Institute
- Paul T. Maruff🇦🇺The University of Melbourne; Florey Institute of Neuroscience and Mental Health
- Ralph Nigel Martins🇦🇺Edith Cowan University
- Jonathan M. Hodgson🇦🇺Edith Cowan University; The University of Western Australia; Royal Perth Hospital; Hospital Research Foundation; RPH Research Foundation
- Catherine P. Bondonno🇦🇺 · autor de correspondenciaEdith Cowan University; The University of Western Australia; Royal Perth Hospital; Hospital Research Foundation; RPH Research Foundation
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Dietary nitrate improves cardiovascular health via a nitric oxide (NO) pathway. NO is key to both cardiovascular and brain health. There is also a strong association between vascular risk factors and brain health. Dietary nitrate intake could therefore be associated with better cognitive function and reduced risk of cognitive decline. This is yet to be investigated. The aim of this study was to investigate the association between habitual intake of dietary nitrate from sources where nitrate is naturally present, and cognitive function, and cognitive decline, in the presence or absence of the apolipoprotein E (APOE) ε4 allele.
Methods
The study included 1254 older adult participants of the Australian Imaging, Biomarkers and Lifestyle Study of Ageing who were cognitively normal at baseline. Plant-derived, vegetable-derived, animal derived nitrate (not including meat where nitrate is an allowed additive), and total nitrate intakes were calculated from baseline food frequency questionnaires using comprehensive nitrate databases. Cognition was assessed at baseline and every 18 months over a follow-up period of 126 months using a comprehensive neuropsychological test battery. Multivariable-adjusted linear mixed effect models were used to examine the association between baseline nitrate intake and cognition over the 126 months (median [IQR] follow-up time of 36 [18-72] months), stratified by APOE ε4 carrier status.
Results
In non APOE ε4 carriers, for every 60 mg/day higher intake of plant-derived nitrate at baseline there was an associated higher language score [β (95% CI): 0.10 (0.01, 0.19)] over 126 months, after multivariable adjustments. In APOE ε4 carriers, there was an associated better episodic recall memory [0.24 (0.08, 0.41)] and recognition memory [0.15 (0.01, 0.30)] scores. Similar associations were seen for the intakes of vegetable-derived and total nitrate. Additionally, in APOE ε4 carriers, for every 6 mg/day higher intake of animal-derived nitrate (excluding meat with nitrate as an allowed additive) at baseline there was an associated higher executive function score [β (95% CI): 1.41 (0.42, 2.39)]. We did not find any evidence of an association between dietary nitrate intake and rate of cognitive decline.
Conclusion
Our results suggest that habitual intake of dietary nitrate from sources where nitrate is naturally present impacts cognitive performance in an APOE genotype contingent manner. Further work is needed to validate our findings and understand potential mechanisms underlying the observed effects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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