Effects of olive oil and flaxseed consumption in a healthy diet on endothelial function, plasma lipids and inflammatory factors of patients with coronary heart disease: a randomized clinical trial
Khandouzi N, Zahedmehr A, Asadian S, Nasrollahzadeh J
Coronary artery disease · 6 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-06-05 · Coron Artery Dis · vol. 34 · número 5 · págs. 332–340
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 9 citas · más que el 78% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Nuts composition and effects
- Palabras clave
- olive oil, flaxseed, coronary artery disease, endothelial function, flow-mediated dilation, inflammation, plasma lipids, interleukin-6, TNF-α, C-reactive protein, MCP-1, non-HDL cholesterol, healthy eating, secondary prevention
- MeSH
- humans, flax, coronary disease, cholesterol, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, olive oil, diet, healthy
4 autores
- Nafiseh Khandouzi🇮🇷Shahid Beheshti University of Medical Sciences
- Ali Zahedmehr
- Sanaz Asadian🇮🇷Iran University of Medical Sciences
- Javad Nasrollahzadeh🇮🇷 · autor de correspondenciaShahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
A healthy lifestyle, including a healthy diet has been associated with an improvement in cardiovascular risk factors. The aim of the present study was to assess the effect of olive oil and flaxseed consumption as part of a healthy diet on endothelial function, plasma inflammatory factors, and lipid profile in patients with coronary heart disease (CHD).
Method
This randomized nonblinded trial was performed on CHD patients. In the control group, participants received general heart-healthy dietary recommendations while in the intervention group, in addition to these recommendations, the participants consumed 25 ml of olive oil and 30 g of flaxseeds daily for 3 months. At baseline and after 3 months, changes in brachial flow-mediated dilation (FMD), plasma asymmetric dimethyl arginine, interleukin-6 (IL-6), IL-10, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and lipids and lipoproteins were measured.
Results
A total of 50 patients finished the trial ( n = 24 in the intervention and n = 26 in the control groups). Compared to the control group, consumption of flaxseed and olive oil significantly improved brachial artery FMD%, and reduced plasma IL-6, TNF-α, MCP-1, total cholesterol, and tended to reduce hs-CRP, and non-HDL-cholesterol but the concentration of other study indices were not different between the two groups.
Conclusion
Inclusion of olive oil and flaxseed in the diet of CHD patients may contribute to secondary prevention by improving endothelial function and plasma inflammatory factors.
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