Urinary 2- to 16α-hydroxyestrone ratio did not change with cruciferous vegetable intake in premenopausal women
Davis SJ, Arscott SA, Goltz S, Muir C, Binkley N, Tanumihardjo SA
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 1 cita
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-06-19 · Int J Vitam Nutr Res · vol. 94 · número 3-4 · págs. 177–186
- Editorial
- Hogrefe Verlag
- Citado
- 1 cita · más que el 47% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytoestrogen effects and research · Genomics, phytochemicals, and oxidative stress · Estrogen and related hormone effects
- Palabras clave
- cruciferous vegetables, Brussels sprouts, kale, broccoli, breast cancer risk biomarkers, premenopausal women, dietary supplements, body fat distribution
- MeSH
- humans, brassicaceae, brassica, vegetables, breast neoplasms, hydroxyestrones, diet, premenopause, dietary supplements, adult, middle aged, female, biomarkers
6 autores
- Stephanie J. Davis🇺🇸University of Wisconsin–Madison
- Sara A. Arscott🇺🇸Wisconsin Department of Transportation; University of Wisconsin–Madison
- Shellen R. Goltz🇺🇸University of Wisconsin–Madison
- Cassidy Muir🇺🇸University of Wisconsin–Madison
- Neil Binkley🇺🇸University of Wisconsin–Madison
- Sherry Ann Tanumihardjo🇺🇸University of Wisconsin–Madison
Resumen
El texto original del estudio, en el idioma en que se publicó.
The mass ratio of urinary 2-hydroxyestrone to 16-α-hydroxyestrone (2:16) is hypothesized as a biomarker of breast cancer risk in premenopausal women, with higher ratios being theoretically protective. Cruciferous vegetable intake has been associated with higher urinary 2:16 in some studies. We investigated whether a whole-food supplement made from dried Brussels sprouts and kale would increase urinary 2:16 in comparison with placebo or cruciferous vegetables in women. This randomized, parallel arm, placebo-controlled, partly blinded study included 78 healthy premenopausal women (38-50 y) with screening urinary 2:16 ≤3.0. Subjects received either six capsules containing 550 mg dried Brussels sprouts and kale per capsule, 40 g daily alternating broccoli or Brussels sprouts, or placebo for eight weeks. Urinary 2:16 and creatinine were measured at baseline, four, and eight weeks. Intent-to-treat repeated measures-ANOVA with multiple imputation (n=100) for missing values identified no treatment effect (P=0.9) or treatment-by-time interaction (P=0.6); however, a significant time effect was noted (P=0.02). Per-protocol analyses including complete cases found no treatment effect (P=1) or treatment-by-time interaction (P=0.6); however, the significant time effect remained (P=0.03). Restricting analysis to subjects with >80% compliance maintained the time effect (P=0.02). Using Pearson correlations, android-pattern and android:gynoid fat were predictive of change (P≤0.05). In conclusion, neither cruciferous supplements nor an added vegetable serving altered urinary 2:16 in premenopausal women with eight weeks treatment. This ratio did vary with time, which is important for designing future trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.