Financiado en parte por Novo Nordisk, Novo Nordisk Fonden
Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice
In Het Panhuis W, Schönke M, Modder M, Tom HE, Lalai RA, Pronk ACM, Streefland TCM, van Kerkhof LWM, Dollé MET, Depuydt MAC, Bot I, Vos WG, Bosmans LA, van Os BW, Lutgens E, Rensen PCN, Kooijman S
EBioMedicine · 28 citas
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Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Ministerie van Sociale Zaken en Werkgelegenheid
- Gobierno
- Deutsche Forschungsgemeinschaft
- Organización sin fines de lucro
- Hartstichting
- Gobierno
- Ministerie van Volksgezondheid, Welzijn en Sport
- Universidad u hospital
- Academisch Medisch Centrum
- Gobierno
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Empresa
- Novo Nordisk
- Empresa
- Novo Nordisk Fonden
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers
- Gobierno
- European Research Council
- Gobierno
- Rijksinstituut voor Volksgezondheid en Milieu
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (P01- AG017242); Ministerie van Sociale Zaken en Werkgelegenheid (1292.19.077); Novo Nordisk Fonden (NNF18OC0032394); Deutsche Forschungsgemeinschaft (SFB1123); Ministerie van Volksgezondheid, Welzijn en Sport (AG-17242); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (1292.19.077); Hartstichting (2017T016); Ministerie van Volksgezondheid, Welzijn en Sport (1292.19.077)
Según 14 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-06-24 · EBioMedicine · vol. 93 · pág. 104680
- Editorial
- Elsevier BV
- Citado
- 31 citas · más que el 93% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Circadian rhythm and melatonin · Dietary Effects on Health · Sleep and Work-Related Fatigue
- Palabras clave
- Circadian rhythm, Internal medicine, Endocrinology, Cholesterol, Apolipoprotein E, Apolipoprotein B, Endogeny, Medicine, Biology, Disease
- MeSH
- animals, humans, mice, hypercholesterolemia, cholesterol, circadian rhythm, photoperiod, female, atherosclerosis, apolipoprotein e3, cholesterol ester transfer proteins
17 autores
- Wietse In het Panhuis🇳🇱Leiden University; University of Applied Sciences Leiden; Leiden University Medical Center
- Milena Schönke🇳🇱Leiden University Medical Center
- Melanie Modder🇳🇱Leiden University Medical Center
- Hannah E. Tom🇳🇱Leiden University Medical Center
- Reshma A. Lalai🇳🇱Leiden University Medical Center
- Amanda C. M. Pronk🇳🇱Leiden University Medical Center
- Trea C.M. Streefland🇳🇱Leiden University Medical Center
- Linda W. M. van Kerkhof🇳🇱National Institute for Public Health and the Environment
- Martijn E.T. Dollé🇳🇱National Institute for Public Health and the Environment
- Marie A.C. Depuydt🇳🇱Leiden University; Centre for Human Drug Research
- Ilze Bot🇳🇱Leiden University; Centre for Human Drug Research
- Winnie G. Vos🇳🇱Amsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; University of Amsterdam
- Laura A. Bosmans🇳🇱Amsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; University of Amsterdam
- Bram W. van Os🇳🇱Amsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; University of Amsterdam
- Esther Lutgens🇳🇱🇺🇸Amsterdam Neuroscience; Mayo Clinic in Arizona; Amsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; University of Amsterdam
- Patrick C.N. Rensen🇳🇱Leiden University Medical Center
- Sander Kooijman🇳🇱 · autor de correspondenciaLeiden University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently occurs during shift work. Shift work has been associated with elevated risk for atherosclerotic cardiovascular disease (asCVD) in humans, but evidence for the effectiveness of prevention strategies is lacking.
Methods
Here, we applied time-restricted feeding (TRF) as a strategy to counteract atherosclerosis development during CD in female APOE∗3-Leiden.CETP mice, a well-established model for humanized lipoprotein metabolism. Control groups were subjected to a fixed 12:12 h light-dark cycle, while CD groups were subjected to 6-h phase advancement every 3 days. Groups had either ad libitum (AL) access to food or were subjected to TRF with restricted food access to the dark phase.
Findings
TRF did not prevent the increase in the relative abundance of circulating inflammatory monocytes and elevation of (postprandial) plasma triglycerides during CD. Nonetheless, TRF reduced atherosclerotic lesion size and prevented an elevation in macrophage content of atherosclerotic lesions during CD, while it increased the relative abundance of anti-inflammatory monocytes, prevented activation of T cells, and lowered plasma total cholesterol levels and markers of hepatic cholesterol synthesis. These effects were independent of total food intake.
Interpretation
We propose that time restricted eating could be a promising strategy for the primary prevention of asCVD risk in shift workers, which warrants future study in humans.
Funding
This work was funded by the Novo Nordisk Foundation, the Netherlands Ministry of Social Affairs and Employment, Amsterdam Cardiovascular Sciences, and the Dutch Heart Foundation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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