Association between ultra-processed foods and risk of cancer: a systematic review and meta-analysis
Lian Y, Wang GP, Chen GQ, Chen HN, Zhang GY
Frontiers in nutrition · 26 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shandong First Medical University
- Subvenciones
- Shandong First Medical University (2019QL013)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-06-08 · Front Nutr · vol. 10 · pág. 1175994
- Editorial
- Frontiers Media
- Citado
- 44 citas · más que el 93% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Biochemical Analysis and Sensing Techniques · Nutrition, Genetics, and Disease
- Palabras clave
- Medicine, Meta-analysis, Colorectal cancer, Subgroup analysis, Internal medicine, Breast cancer, Oncology, Prostate cancer, Prospective cohort study, Cohort study, Cancer, Publication bias, Gynecology
5 autores
- Ying Lian🇨🇳Shandong Provincial QianFoShan Hospital; Shandong First Medical University
- Gangpu Wang🇨🇳The Fourth People's Hospital; Fourth People’s Hospital of Jinan
- Guoqiang Chen🇨🇳Shandong Provincial QianFoShan Hospital; Shandong First Medical University
- Huanan Chen🇨🇳Shandong Provincial QianFoShan Hospital; Shandong First Medical University
- Guangyong Zhang🇨🇳 · autor de correspondenciaShandong Provincial QianFoShan Hospital; Shandong First Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Despite increasing evidence that has shown the association of ultra-processed foods (UPFs) with cancer risk, the results remain inconclusive. We, therefore, conducted the meta-analysis to clarify the association by including recently published studies.
Methods
A comprehensive search was conducted in PubMed, Embase, and Web of Science to identify all relevant studies from inception to January 2023. To pool data, fixed-effects or random-effects models were used where appropriate. Subgroup analyses, sensitivity analyses, and publication bias tests were performed.
Results
A total of 13 studies (4 cohort studies and 9 case-control studies) were included in the analysis, with a total of 625,738 participants. The highest UPFs consumption was associated with increased risk of colorectal cancer (OR = 1.23, 95% CI: 1.10-1.38), colon cancer (OR = 1.25, 95% CI: 1.14-1.36), and breast cancer (OR = 1.10, 95% CI: 1.00-1.20) but not rectal cancer (OR = 1.18, 95% CI: 0.97-1.43) and prostate cancer (OR = 1.03, 95% CI: 0.93-1.12). In addition, the subgroup analyses showed that a positive association between UPFs consumption and colorectal cancer was observed among men (OR = 1.31, 95% CI: 1.15-1.50), whereas no significant association was observed among women (OR = 1.10, 95% CI: 0.94-1.29).
Conclusion
The present meta-analysis suggests that high UPFs consumption is associated with a significantly increased risk of certain site-specific cancers, especially the digestive tract and some hormone-related cancers. However, further rigorously designed prospective and experimental studies are needed to better understand causal pathways.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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