Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population : A Randomized Controlled Trial
Lin S, Cienfuegos S, Ezpeleta M, Gabel K, Pavlou V, Mulas A, Chakos K, McStay M, Wu J, Tussing-Humphreys L, Alexandria SJ, Sanchez J, Unterman T, Varady KA
Annals of internal medicine · 109 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK128180); National Cancer Institute (R01CA257807); National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK128782)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2023-06-26 · Ann Intern Med · vol. 176 · número 7 · págs. 885–895
- Editorial
- American College of Physicians
- Citado
- 148 citas · más que el 100% de estudios similares · 20.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Enhanced Recovery After Surgery
- Palabras clave
- Medicine, Weight loss, Calorie, Randomized controlled trial, Obesity, Population, Calorie restriction, Weight gain, Internal medicine, Weight change, Animal science, Body weight
- MeSH
- humans, obesity, weight loss, caloric restriction, energy intake, adult, chicago
14 autores
- Shuhao Lin🇺🇸University of Illinois Chicago
- Sofia Cienfuegos🇺🇸University of Illinois Chicago
- Mark Ezpeleta🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Vasiliki Pavlou🇺🇸University of Illinois Chicago
- Andrea Mulas🇺🇸University of Illinois Chicago
- Kaitie Chakos🇺🇸University of Illinois Chicago
- Mara McStay🇺🇸University of Illinois Chicago
- Jackie Q. Wu🇺🇸University of Illinois Chicago
- Lisa M. Tussing‐Humphreys🇺🇸University of Illinois Chicago
- Shaina J. Alexandria🇺🇸Northwestern University
- Julienne Sánchez🇺🇸University of Illinois Chicago
- Terry G. Unterman🇺🇸University of Illinois Chicago; Jesse Brown VA Medical Center
- Krista A Varady🇺🇸University of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited.
Objective
To determine whether TRE is more effective for weight control and cardiometabolic risk reduction compared with calorie restriction (CR) or control.
Design
12-month randomized controlled trial. (ClinicalTrials.gov: NCT04692532).
Setting
University of Illinois Chicago from January 2021 to September 2022.
Participants
90 adults with obesity.
Intervention
8-hour TRE (eating between noon and 8:00 p.m. only, without calorie counting), CR (25% energy restriction daily), or control (eating over a period of 10 or more hours per day). Participants were not blinded.
Measurements
Change in body weight, metabolic markers, and energy intake by month 12.
Results
Seventy-seven persons completed the study. Mean age was 40 years (SD, 11), 33% were Black, and 46% were Hispanic. Mean reduction in energy intake was -425 kcal/d (SD, 531) for TRE and -405 kcal/d (SD, 712) for CR. Compared with the control group, weight loss by month 12 was -4.61 kg (95% CI, -7.37 to -1.85 kg; P ≤ 0.01) (-4.87% [CI, -7.61% to -2.13%]) for the TRE group and -5.42 kg (CI, -9.13 to -1.71 kg; P ≤ 0.01) (-5.30% [CI, -9.06% to -1.54%]) for the CR group, with no statistically significant difference between TRE and CR (0.81 kg [CI, -3.07 to 4.69 kg; P = 0.68]) (0.43% [CI, -3.48% to 4.34%]).
Limitation
Not blinded, not powered to detect relatively large differences in weight loss, and lack of adjustment for multiple comparisons.
Conclusion
Time-restricted eating is more effective in producing weight loss when compared with control but not more effective than CR in a racially diverse population.
Primary funding source
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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