The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Syndrome: a Randomized Clinical Trial
Shahmoradi S, Chiti H, Tavakolizadeh M, Hatami R, Motamed N, Ghaemi M
Biological trace element research · 18 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-07-02 · Biol Trace Elem Res · vol. 202 · número 3 · págs. 941–946
- Editorial
- Springer Science+Business Media
- Citado
- 25 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ovarian function and disorders · Magnesium in Health and Disease · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- magnesium supplementation, magnesium oxide, polycystic ovary syndrome, insulin resistance, lipid profile, serum insulin, fasting blood glucose, HDL cholesterol, LDL cholesterol, total cholesterol, oligomenorrhea, blood pressure, anthropometric parameters, women
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, magnesium, insulin, blood glucose, lipids, double-blind method, dietary supplements, adolescent, adult, female, metabolome, young adult
6 autores
- Shabnam Shahmoradi🇮🇷Zanjan University of Medical Sciences
- Hossein Chiti🇮🇷Zanjan University of Medical Sciences
- Mahdi Tavakolizadeh🇮🇷Zanjan University of Medical Sciences
- Robabeh Hatami🇮🇷 · autor de correspondenciaZanjan University of Medical Sciences
- Nima Motamed🇮🇷Zanjan University of Medical Sciences
- Marjan Ghaemi🇮🇷Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Due to the definitive known effect of magnesium on insulin resistance and the fact that insulin resistance is a main etiology in polycystic ovary syndrome (PCOS), it is assumed the use of magnesium supplements can improve insulin resistance, lipid profiles, and glucose and thus may also play a role in improving the clinical condition of patients with PCOS. We aimed to assess the effects of magnesium supplements on anthropometric, clinical, and metabolic parameters in women suffering from PCOS. This triple-blind randomized clinical trial study was conducted on women aged 15-35 years with PCOS. The patients were randomly assigned to receive a magnesium oxide supplement (250 mg/day for 2 months) or a placebo. The study parameters were evaluated and compared between two groups before as well as 2 months and 5 months after the initial assessment. In total, 40 cases (20 in each group) were recruited in the study. A significant reduction in the serum insulin level (P-value = 0.036) and insulin resistance (p-value = 0.032) was observed in the case group. Prescribing magnesium supplements could also lead to lowering total cholesterol, low-density lipoprotein, and fasting blood sugar along with increasing the level of high-density lipoprotein. We could not find any significant difference in anthropometric parameters as well as the mean systolic and diastolic blood pressures before and after intervention between the two groups. Although the rate of oligomenorrhea significantly decreased in the two study groups, it was no different across the two groups before and also after the intervention. The use of magnesium supplements in patients with PCO, regardless of the etiology or progression of the disease, can greatly improve the metabolic status of these patients by improving insulin resistance and modulating the level of lipid profile.
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