Effects of Withania somnifera (Ashwagandha) on Hematological and Biochemical Markers, Hormonal Behavior, and Oxidant Response in Healthy Adults: A Systematic Review
Gómez Afonso A, Fernandez-Lazaro D, Adams DP, Monserdà-Vilaró A, Fernandez-Lazaro CI
Current nutrition reports · 39 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidad de Valladolid
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-07-10 · Curr Nutr Rep · vol. 12 · número 3 · págs. 465–477
- Editorial
- Springer Science+Business Media
- Citado
- 54 citas · más que el 98% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants
- Palabras clave
- Withania somnifera, Medicine, Adverse effect, Traditional medicine, Randomized controlled trial, Meta-analysis, Systematic review, Hormone, Physiology, Alternative medicine, Internal medicine, MEDLINE, Biology, Pathology
- MeSH
- humans, withania, hormones, plant extracts, oxidants, adult, biomarkers
5 autores
- Adrián Gómez Afonso🇪🇸Universidad Europea de Madrid
- Diego Fernández‐Lázaro🇪🇸 · autor de correspondenciaUniversidad de Valladolid
- David P. Adams🇮🇪Ollscoil na Gaillimhe – University of Galway
- Aniol Monserdà-Vilaró🇪🇸Universidad Europea de Madrid
- Cesar Ignacio Fernandez-Lazaro🇪🇸 · autor de correspondenciaNavarre Institute of Health Research; Universidad de Navarra
Resumen
El texto original del estudio, en el idioma en que se publicó.
PURPOSE OF REVIEW: Withania somnifera (L.) Dunal (Ws) is a common herb plant that has been used for centuries to treat a wide range of conditions, particularly certain chronic diseases due to its antidiabetic, cardioprotective, antistress, and chondroprotective effects, among many others. No conclusive evidence, however, exists about the potential health effects of Ws in adults without chronic conditions. We aimed to evaluate the current evidence on the health benefits of Ws supplementation in healthy adults. RECENT FINDINGS: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed studies indexed in Web of Science, Scopus, and PubMed to assess the effects of Ws on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults. Original articles published up to March 5, 2022, with a controlled trial design or pre-post intervention design, in which supplementation of Ws was compared to a control group or data prior to intervention were included. Among 2,421 records identified in the search, 10 studies met the inclusion criteria. Overall, most of the studies reported beneficial effects of the Ws supplementation, and no serious adverse events were reported. Participants supplemented with Ws displayed reduced levels of oxidative stress and inflammation, and counterbalanced hormone levels. No evidence of the beneficial effects of Ws supplementation on hematological markers was reported. Ws supplementation appears to be safe, may regulate hormone levels, and has potent anti-inflammatory and antioxidant effects. However, further studies are needed to elucidate the relevance of its application.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.