The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis
Burke R, Piñero A, Coleman M, Mohan A, Sapuppo M, Augustin F, Aragon AA, Candow DG, Forbes SC, Swinton P, Schoenfeld BJ
Nutrients · 40 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-04-28 · Nutrients · vol. 15 · número 9 · pág. 2116
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 77 citas · más que el 93% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Nutrition and Health in Aging
- Palabras clave
- Muscle hypertrophy, Creatine, Medicine, Magnetic resonance imaging, Meta-analysis, Placebo, Internal medicine, Creatine Monohydrate, Creatine kinase, Randomized controlled trial, Ultrasound, Univariate analysis, Resistance training, Cardiology, Endocrinology, Multivariate analysis, Radiology, Pathology
- MeSH
- muscles, humans, hypertrophy, creatine, dietary supplements, aged, resistance training
11 autores
- Ryan Burke🇺🇸Lehman College
- Alec Piñero🇺🇸Lehman College
- Max Coleman🇺🇸Lehman College
- Adam Eithen Mohan🇺🇸Lehman College
- Max Sapuppo🇺🇸Lehman College
- Francesca Augustin🇺🇸Lehman College
- Alan Albert Aragon🇺🇸California State University, Northridge
- Darren Glenn Candow🇨🇦University of Regina
- Scott C. Forbes🇨🇦Brandon University
- Paul Alan Swinton🇬🇧Robert Gordon University
- Brad Jon Schoenfeld🇺🇸 · autor de correspondenciaLehman College
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this paper was to carry out a systematic review with a meta-analysis of randomized controlled trials that examined the combined effects of resistance training (RT) and creatine supplementation on regional changes in muscle mass, with direct imaging measures of hypertrophy. Moreover, we performed regression analyses to determine the potential influence of covariates. We included trials that had a duration of at least 6 weeks and examined the combined effects of creatine supplementation and RT on site-specific direct measures of hypertrophy (magnetic resonance imaging (MRI), computed tomography (CT), or ultrasound) in healthy adults. A total of 44 outcomes were analyzed across 10 studies that met the inclusion criteria. A univariate analysis of all the standardized outcomes showed a pooled mean estimate of 0.11 (95% Credible Interval (CrI): -0.02 to 0.25), providing evidence for a very small effect favoring creatine supplementation when combined with RT compared to RT and a placebo. Multivariate analyses found similar small benefits for the combination of creatine supplementation and RT on changes in the upper and lower body muscle thickness (0.10-0.16 cm). Analyses of the moderating effects indicated a small superior benefit for creatine supplementation in younger compared to older adults (0.17 (95%CrI: -0.09 to 0.45)). In conclusion, the results suggest that creatine supplementation combined with RT promotes a small increase in the direct measures of skeletal muscle hypertrophy in both the upper and lower body.
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