Effect of time restricted feeding on anthropometric measures, eating behavior, stress, serum levels of BDNF and LBP in overweight/obese women with food addiction: a randomized clinical trial
Irani H, Abiri B, Khodami B, Yari Z, Lafzi Ghazi M, Hosseinzadeh N, Saidpour A
Nutritional neuroscience · 17 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National Nutrition and Food Technology Research Institute
Según 1 financiador declarado.
Publicación
- Publicado
- 2023-07-12 · Nutr Neurosci · vol. 27 · número 6 · págs. 577–589
- Editorial
- Taylor & Francis
- Citado
- 25 citas · más que el 94% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 100 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Eating Disorders and Behaviors · Regulation of Appetite and Obesity
- Palabras clave
- time-restricted feeding, food addiction, obesity, overweight women, brain-derived neurotrophic factor, lipopolysaccharide-binding protein, gut microbiota, dietary habits, hypocaloric diet, weight loss, stress, cognitive restriction, fasting, body composition, waist circumference, body mass index, fat mass, serum biomarkers, eating disorder treatment, eating disorder prevention
- MeSH
- humans, obesity, brain-derived neurotrophic factor, membrane glycoproteins, anthropometry, body mass index, caloric restriction, fasting, feeding behavior, stress, psychological, adult, middle aged, female, overweight, waist circumference, food addiction, intermittent fasting
7 autores
- Hanieh Irani🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Behnaz Abiri🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Banafsheh Khodami🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Zahra Yari🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Maryam Lafzi Ghazi🇮🇷Islamic Azad University, Tehran; Islamic Azad University Central Tehran Branch
- Nima Hosseinzadeh🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Atoosa Saidpour🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aim
Food addiction (FA) as a specific food-related behavior may play an essential role in the pathogenesis of obesity. Brain-derived neurotrophic factor (BDNF) and gut microbiota (GM) alterations probably through fasting are closely related to brain function, affecting eating behaviors and body weight management. This study aimed to evaluate the effect of time-restricted feeding (TRF) on serum BDNF levels and eating behaviors in overweight and obese women with FA.
Methods and design
This clinical trial was performed with a 2-month follow-up on 56 obese and overweight women with FA. Participants were randomly divided into two groups receiving a low-calorie diet (n = 27) and a group receiving a low-calorie diet with TRF (n = 29). Anthropometric measurements, biochemical markers, eating behavior, and stress were assessed during the study period.
Results
The reductions in weight, body mass index (BMI), waist circumference, and body fat mass were significantly higher in the TRF group compared to the control group at week 8 (P = 0.018, P = 0.015. P = 0.03, and P = 0.036, respectively). The cognitive restriction score was higher in the TRF as compared with the control group (P = 0.002). The food addiction criteria score was significantly reduced in both groups (P P P P = 0.618). Lipopolysaccharide binding protein decreased significantly in both groups, but this decrease was significantly higher in the TRF group than in the control group (P < 0.001).
Conclusion
The results of this study showed that a low-calorie diet with TRF is more effective in weight management than a low-calorie diet alone, probably through further modulating the GM and improving BDNF levels. More effective weight loss in the TRF is probably related to better management of eating behavior than FA.
Trial registration
Iranian Registry of Clinical Trials identifier: IRCT20131228015968N7.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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