Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype
Dunk MM, Li J, Liu S, Casanova R, Chen JC, Espeland MA, Hayden KM, Manson JE, Rapp SR, Shadyab AH, Snetselaar LG, Van Horn L, Wild R, Driscoll I
Alzheimer's & dementia : the journal of the Alzheimer's Association · 42 citas
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Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- Women's Health Initiative
- Universidad u hospital
- University of Wisconsin-Milwaukee
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NIA NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Institute on Aging (R01AG074345); National Heart, Lung, and Blood Institute (HHSN268201600018C); National Institute on Aging (HHSN-271-2011-00004C,); National Heart, Lung, and Blood Institute (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600001C); National Heart, Lung, and Blood Institute (HHSN271201100004C); National Institute on Aging (P30 AG072947); U.S. Department of Health and Human Services (HHSN-271-2011-00004C); National Institute on Aging (RF1 AG079149); National Institute on Aging (RF1 AG074345); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2023-07-12 · Alzheimers Dement · vol. 19 · número 12 · págs. 5742–5754
- Editorial
- Wiley
- Citado
- 53 citas · más que el 98% de estudios similares · 7.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Alzheimer's disease research and treatments · Nutritional Studies and Diet · Dementia and Cognitive Impairment Research
- Palabras clave
- Dementia, Apolipoprotein E, Mendelian randomization, Internal medicine, Cholesterol, Odds ratio, Blood lipids, Lipoprotein, Endocrinology, Medicine, Risk factor, Gerontology, Biology, Disease, Genotype, Biochemistry
- MeSH
- humans, dementia, cholesterol, cholesterol, dietary, triglycerides, apolipoproteins e, risk factors, genotype, aged, female, apolipoprotein e4
14 autores
- Michelle M. Dunk🇸🇪🇺🇸Karolinska Institutet; University of Wisconsin–Milwaukee
- Jie Li🇺🇸🇨🇳Rhode Island Department of Health; Brown University; Guangdong Academy of Medical Sciences; Guangdong Provincial People's Hospital
- Simin Liu🇺🇸Rhode Island Department of Health; Brown University
- Ramon Casanova🇺🇸Wake Forest University
- Jiu‐Chiuan Chen🇺🇸University of Southern California
- Mark Andrew Espeland🇺🇸Wake Forest University
- Kathleen M. Hayden🇺🇸Wake Forest University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Stephen R. Rapp🇺🇸Wake Forest University
- Aladdin H. Shadyab🇺🇸University of California San Diego; Human Longevity (United States)
- Linda G. Snetselaar🇺🇸University of Iowa
- Linda Van Horn🇺🇸Northwestern University
- Robert A. Wild🇺🇸OU Health; University of Oklahoma Health Sciences Center
- Ira Frahmand Driscoll🇺🇸 · autor de correspondenciaUniversity of Wisconsin–Madison; University of Wisconsin–Milwaukee
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Whether apolipoprotein E's (APOE's) involvement in lipid metabolism contributes to Alzheimer's disease (AD) risk remains unknown.
Methods
Incident probable dementia and cognitive impairment (probable dementia+mild cognitive impairment) were analyzed in relation to baseline serum lipids (total, low-density lipoprotein [LDL], high-density lipoprotein [HDL], non-HDL cholesterol, total-to-HDL, LDL-to-HDL, remnant cholesterol, and triglycerides) using Mendelian randomization in 5358 postmenopausal women from the Women's Health Initiative Memory Study. We also examined associations of baseline dietary cholesterol and fat with lipids based on APOE status.
Results
After an average of 11.13 years, less favorable lipid levels related to greater dementia and cognitive impairment risk. Dementia (odds ratio [OR] = 3.13; 95% confidence interval [CI]: 2.31 to 4.24) and cognitive impairment (OR = 2.38; 95% CI: 1.85 to 3.06) risk were greatest in relation to higher remnant cholesterol levels. Greater cholesterol consumption related to poorer lipids in APOE4+ compared to APOE3 carriers.
Discussion
APOE4+ carriers consuming more cholesterol had less favorable lipids, which were associated with greater dementia and cognitive impairment risk.
Highlights
Less favorable serum lipids were associated with higher dementia incidence. Mendelian randomization findings suggest causality between lipids and dementia. Lipid levels in older women may be clinical indicators of dementia risk. APOE4 carriers had poorest lipid profiles in relation to cholesterol consumption. APOE risk for dementia may be modifiable through lipid management.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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