Financiado en parte por U.S. Highbush Blueberry Council
Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial
Nieman DC, Sakaguchi CA, Omar AM, Davis KL, Shaffner CE, Strauch RC, Lila MA, Zhang Q
Scientific reports · 17 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056350)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-07-24 · Sci Rep · vol. 13 · número 1 · pág. 11976
- Editorial
- Nature Portfolio
- Citado
- 24 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Phytochemicals and Antioxidant Activities · Fatty Acid Research and Health
- Palabras clave
- oxylipins, post-exercise inflammation, muscle soreness, muscle damage, specialized pro-resolving mediators, docosahexaenoic acid, linoleic acid, lipoxygenase, cytochrome P450, anthocyanins, eccentric exercise
- MeSH
- humans, anthocyanins, docosahexaenoic acids, eicosapentaenoic acid, anti-inflammatory agents, adult, oxylipins, myalgia, blueberry plants
8 autores
- David Christopher Nieman🇺🇸 · autor de correspondenciaAppalachian State University
- Camila A. Sakaguchi🇺🇸Appalachian State University
- Ashraf M. Omar🇺🇸University of North Carolina at Greensboro
- Kierstin L. Davis🇺🇸Appalachian State University
- Cameron E. Shaffner🇺🇸Appalachian State University
- Renee C. Strauch🇺🇸North Carolina State University
- Mary Ann Lila🇺🇸North Carolina State University
- Qibin Zhang🇺🇸University of North Carolina at Greensboro
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study determined if 18 days of supplementation with blueberries (BL) compared to placebo (PL) could mitigate muscle soreness and damage and improve inflammation resolution in untrained adults (n = 49, ages 18-50 years) after engaging in a 90-min bout of "weekend warrior" eccentric exercise. The BL freeze dried supplement provided 1 cup of fresh blueberries per day equivalent with 805 mg/day total phenolics and 280 mg/day anthocyanins. Urine levels of eight BL gut-derived phenolics increased after 14- and 18-days supplementation with 83% higher concentrations in BL vs. PL (p < 0.001). The 90-min exercise bout caused significant muscle soreness and damage during 4d of recovery and a decrease in exercise performance with no significant differences between PL and BL. Plasma oxylipins were identified (n = 76) and grouped by fatty acid substrates and enzyme systems. Linoleic acid (LA) oxylipins generated from cytochrome P450 (CYP) (9,10-, 12,13-dihydroxy-9Z-octadecenoic acids) (diHOMEs) were lower in BL vs. PL (treatment effect, p = 0.051). A compositive variable of 9 plasma hydroxydocosahexaenoic acids (HDoHEs) generated from docosahexaenoic acid (DHA, 22:6) and lipoxygenase (LOX) was significantly higher in BL vs. PL (treatment effect, p = 0.008). The composite variable of plasma 14-HDoHE, 17-HDoHE, and the eicosapentaenoic acid (EPA)-derived oxylipin 18-hydroxyeicosapentaenoic acid (18-HEPE) (specialized pro-resolving lipid mediators, SPM, intermediates) was significantly higher in BL vs PL (treatment effect, p = 0.014). Pearson correlations showed positive relationships between post-exercise DHA-LOX HDoHEs and SPM intermediates with urine blueberry gut-derived phenolics (r = 0.324, p = 0.023, and r = 0.349, p = 0.015, respectively). These data indicate that 18d intake of 1 cup/day blueberries compared to PL was linked to a reduction in pro-inflammatory diHOMES and sustained elevations in DHA- and EPA-derived anti-inflammatory oxylipins in response to a 90-min bout of unaccustomed exercise by untrained adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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