Dietary nitrate intake in relation to the risk of dementia and imaging markers of vascular brain health: a population-based study
de Crom TOE, Blekkenhorst L, Vernooij MW, Ikram MK, Voortman T, Ikram MA
The American journal of clinical nutrition · 16 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Organización sin fines de lucro
- National Heart Foundation of Australia
- Gobierno
- ZonMw
- Universidad u hospital
- Erasmus Universiteit Rotterdam
- Gobierno
- Ministerie van Volksgezondheid, Welzijn en Sport
- Universidad u hospital
- Erasmus Medisch Centrum
- Gobierno
- Ministerie van Onderwijs, Cultuur en Wetenschap
- Universidad u hospital
- Vereniging Trustfonds Erasmus Universiteit Rotterdam
- Organización sin fines de lucro
- Alzheimer Nederland
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- Vereniging Trustfonds Erasmus Universiteit Rotterdam (97030.2021.101.430/057/RB); ZonMw (73305095005); National Heart Foundation of Australia (102498); National Heart Foundation of Australia (1172987); National Health and Medical Research Council (1172987)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2023-07-06 · Am J Clin Nutr · vol. 118 · número 2 · págs. 352–359
- Editorial
- Elsevier BV
- Citado
- 20 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Folate and B Vitamins Research · Nutritional Studies and Diet
- Palabras clave
- Medicine, Dementia, Confidence interval, Interquartile range, Vascular dementia, Population, Hazard ratio, Prospective cohort study, Hyperintensity, Internal medicine, Environmental health, Magnetic resonance imaging, Disease, Radiology
- MeSH
- brain, humans, vegetables, nitrates, risk factors, prospective studies, eating, middle aged, female, male
8 autores
- Tosca O. E. de Crom🇳🇱Erasmus MC
- Lauren C. Blekkenhorst🇦🇺Edith Cowan University; Royal Perth Hospital; Hospital Research Foundation; RPH Research Foundation
- Meike Willemijn Vernooij🇳🇱Erasmus MC
- M. Kamran Ikram🇳🇱 · autor de correspondenciaErasmus MC; Erasmus University Rotterdam
- M. Kamran Ikram🇳🇱Erasmus MC; Erasmus University Rotterdam
- Trudy Voortman🇳🇱Erasmus MC
- M. Arfan Ikram🇳🇱Erasmus MC; Erasmus University Rotterdam
- M. Arfan Ikram🇳🇱 · autor de correspondenciaErasmus MC; Erasmus University Rotterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nitric oxide is a free radical that can be produced from dietary nitrate and positively affects cardiovascular health. With cardiovascular health playing an important role in the etiology of dementia, we hypothesized a link between dietary nitrate intake and the risk of dementia.
Objectives
This study aimed to find the association of total, vegetable, and nonvegetable dietary nitrate intake with the risk of dementia and imaging markers of vascular brain health, such as total brain volume, global cerebral perfusion, white matter hyperintensity volume, microbleeds, and lacunar infarcts.
Methods
Between 1990 and 2009, dietary intake was assessed using food-frequency questionnaires in 9543 dementia-free participants (mean age, 64 y; 58% female) from the prospective population-based Rotterdam Study. Participants were followed up for incidence dementia until January 2020. We used Cox models to determine the association between dietary nitrate intake and incident dementia. Using linear mixed models and logistic regression models, we assessed the association of dietary nitrate intake with changes in imaging markers across 3 consecutive examination rounds (mean interval between images 4.6 y).
Results
Participants median dietary nitrate consumption was 85 mg/d (interquartile range, 55 mg/d), derived on average for 81% from vegetable sources. During a mean follow-up of 14.5 y, 1472 participants developed dementia. A higher intake of total and vegetable dietary nitrate was associated with a lower risk of dementia per 50-mg/d increase [hazard ratio (HR): 0.92; 95% confidence interval (CI): 0.87, 0.98; and HR: 0.92; 95% CI: 0.86, 0.97, respectively] but not with changes in neuroimaging markers. No association between nonvegetable dietary nitrate intake and the risk of dementia (HR: 1.15; 95% CI: 0.64, 2.07) or changes in neuroimaging markers were observed.
Conclusions
A higher dietary nitrate intake from vegetable sources was associated with a lower risk of dementia. We found no evidence that this association was driven by vascular brain health.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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