Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials
Wang F, Peng W, Jiang Z
Eye & contact lens · 13 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-08-08 · Eye Contact Lens · vol. 49 · número 10 · págs. 438–446
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 15 citas · más que el 69% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Palabras clave
- Medicine, Meta-analysis, Randomized controlled trial, Confidence interval, Cochrane Library, Subgroup analysis, Orthokeratology, Ophthalmology, Random effects model, Internal medicine, Pediatrics
- MeSH
- humans, myopia, disease progression, atropine, mydriatics, refraction, ocular, phototherapy, child, randomized controlled trials as topic, axial length, eye
3 autores
- Fei Wang🇨🇳Hefei Institutes of Physical Science
- Peng Wei🇨🇳Anhui Medical University; Hefei Institutes of Physical Science; Second Affiliated Hospital of Anhui Medical University
- Zhengxuan Jiang🇨🇳 · autor de correspondenciaAnhui Medical University; Hefei Institutes of Physical Science; Second Affiliated Hospital of Anhui Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Repeated low-level red light (RLRL) therapy has been suggested to be effective in children with myopia. However, evidence from randomized controlled trials (RCTs) is still limited. We performed a meta-analysis of RCTs to systematically evaluate the efficacy of RLRL on changes of axial length (AL) and cycloplegic spherical equivalent refraction (SER) in children with myopia.
Methods
Relevant RCTs were obtained through a search of electronic databases including PubMed, Embase, Cochrane Library, Wanfang, and China National Knowledge Infrastructure from inception to September 15, 2022. A random-effects model was used to pool the results after incorporating the influence of potential heterogeneity. Subgroup analyses were performed according to the control treatment and follow-up duration.
Results
A total of seven RCTs involving 1,031 children with myopia, aged 6 to 16 years, were included in the meta-analysis. Compared with control treatment without RLRL, treatment with RLRL was associated with a significantly reduced AL (mean difference [MD]: -0.25 mm, 95% confidence interval [CI]: -0.32 to -0.17, P <0.001; I 2 =13%) and a significantly increased cycloplegic SER (MD: 0.60 D, 95% CI: 0.44-0.76, P <0.001; I 2 =20%). Further subgroup analyses showed consistent results in studies comparing children wearing single vision lenses and those receiving active treatment including orthokeratology or low-dose atropine eye drops, as well as studies of treatment duration of 6 and 12 months.
Conclusions
Results of the meta-analysis suggested that RLRL treatment is effective for slowing down the progression of myopia in children aged 6 to 16 years.
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