Interaction between Serum Cotinine and Magnesium Intake with Childhood Asthma: A Cross-Sectional Study
Cao J, Liu M, Wang Z, Huang Y, Zheng K
International archives of allergy and immunology · 3 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-01-01 · Int Arch Allergy Immunol · vol. 184 · número 11 · págs. 1090–1098
- Editorial
- Karger Publishers
- Citado
- 5 citas · más que el 64% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Ion Channels and Receptors · Asthma and respiratory diseases
- Palabras clave
- Cross-sectional study, Cotinine, Medicine, Asthma, Immunology, Magnesium, Environmental health, Internal medicine, Chemistry, Nicotine, Pathology
- MeSH
- humans, asthma, magnesium, cotinine, nutrition surveys, cross-sectional studies, tobacco smoke pollution, male
5 autores
- Jianwei Cao🇨🇳Zhongshan People's Hospital
- Meiling Liu🇨🇳Zhongshan People's Hospital
- Zhongquan Wang🇨🇳Zhongshan People's Hospital
- Ying Huang🇨🇳Guangdong Medical College
- Kaijun Zheng🇨🇳Zhongshan People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Serum cotinine and magnesium intake are often associated with childhood asthma. This study evaluated the interaction between serum cotinine and magnesium intake and childhood asthma.
Methods
This cross-sectional study included 14,159 subjects from the National Health and Nutrition Examination Survey 2005-2018. Serum cotinine levels were classified according to the lower quartile: ≤0.2089 ng/mL as low level and >0.2089 ng/mL as high level. Magnesium intake was categorized as high (>98 mg/1,000 kcal) or low level (≤98 mg/1,000 kcal) based on the upper quartile. Weighted logistic regression analyses were adopted to analyze the association between cotinine, magnesium intake, and childhood asthma. Additionally, the combined effect of cotinine and magnesium intake on childhood asthma risk was examined. The stratified analyses were based on gender, body mass index, and family history of asthma to further examine the relationship between cotinine, magnesium intake, and childhood asthma.
Results
The prevalence of asthma was approximately 17.56%. Compared to low-level cotinine, high-level cotinine was associated with asthma (odds ratio [OR] = 1.25, 95% confidence interval (CI): 1.04-1.50). Low-level magnesium intake was related to asthma compared with high-level magnesium intake (OR = 1.21, 95% CI: 1.04-1.40). Using interaction analysis, we also found that the combined effect of cotinine and magnesium intake was associated with childhood asthma risk, and the interaction between high-level cotinine and low-level magnesium intake was associated with the highest risk of childhood asthma (OR = 1.35, 95% CI: 1.04-1.74). Additionally, this interaction was also found in males, overweight/non-overweight, and those with family history of asthma.
Conclusion
There was an interaction between serum cotinine and magnesium intake on childhood asthma. The results suggested that implementing smoking bans in certain settings (e.g., communities, schools) and promoting the consumption of magnesium-rich foods may be effective strategies for preventing childhood asthma.
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