The association of ultra-processed food consumption with adult inflammatory bowel disease risk: a systematic review and dose-response meta-analysis of 4 035 694 participants
Babaei A, Pourmotabbed A, Talebi S, Mehrabani S, Bagheri R, Ghoreishy SM, Amirian P, Zarpoosh M, Mohammadi H, Kermani MAH, Fakhari H, Moradi S
Nutrition reviews · 24 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-08-01 · Nutr Rev · vol. 82 · número 7 · págs. 861–871
- Editorial
- Oxford University Press
- Citado
- 29 citas · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 90 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Inflammatory Bowel Disease · Nutritional Studies and Diet
- Palabras clave
- ultra-processed foods, inflammatory bowel disease, Crohn's disease, ulcerative colitis, dietary risk factors, dose-response relationship, food processing, gut microbiota, intestinal barrier, intestinal permeability, intestinal inflammation, Mediterranean diet, Western diet, dietary diversity
- MeSH
- humans, inflammatory bowel diseases, crohn disease, diet, risk factors, food handling, adult, food, processed
12 autores
- Atefeh Babaei🇮🇷Kermanshah University of Medical Sciences
- Ali Pourmotabbed🇮🇷 · autor de correspondenciaKermanshah University of Medical Sciences
- Sepide Talebi🇮🇷Iran University of Medical Sciences; University of Tehran; Tehran University of Medical Sciences
- Sanaz Mehrabani🇮🇷Isfahan University of Medical Sciences
- Reza Bagheri🇮🇷University of Isfahan
- Seyed Mojtaba Ghoreishy🇮🇷Iran University of Medical Sciences; University of Tehran; Tehran University of Medical Sciences
- Parsa Amirian🇮🇷Kermanshah University of Medical Sciences
- Mahsa Zarpoosh🇮🇷Kermanshah University of Medical Sciences
- Hamed Mohammadi🇮🇷University of Tehran; Tehran University of Medical Sciences
- Mohammad Ali Hojjati Kermani🇮🇷Masih Daneshvari Hospital; Shahid Beheshti University of Medical Sciences
- Hadi Fakhari🇮🇷University of Isfahan
- Sajjad Moradi🇮🇷Kermanshah University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
There is an inconsistency between the results obtained from observational studies regarding intake of ultra-processed foods (UPFs) and the risk of inflammatory bowel disease (IBD).
Objectives
A dose-response meta-analysis was performed to evaluate the relationship between UPF intake and the risk of IBD.
Data sources
Searches were performed in the PubMed, ISI Web of Science, and Scopus databases up to November 2, 2022.
Data extraction
Data were available from 24 studies including a total of 4 035 694 participants from 20 countries.
Data analysis
Risk ratios for IBD were analyzed by a random-effects model. Outcomes indicated that UPF intake was linked to an increased risk of IBD (relative risk [RR], 1.13; 95%CI, 1.06-1.21; P = 0.001; I2 = 73.2%; n = 59; N = 4 035 694). This association was significant, especially for the risk of Crohn's disease (CD) (RR, 1.19; 95%CI, 1.00-1.41; I2 = 78.2%; P = 0.046; n = 23; N = 2 167 160), unlike the risk of ulcerative colitis (UC) (RR = 1.11; 95%CI, 0.99-1.26; P = 0.085; I2 = 60.3%; n = 27; N = 2 167 918). Also, results revealed that each 10% enhancement in daily UPF intake was not related to the risk of IBD (RR, 1.05; 95%CI, 0.98-1.14; P = 0.168; I2 = 31.9%; n = 4) or the risk of UC (RR, 1.01; 95%CI, 0.92-1.11; P = 0.876; I2 = 34.7%; n = 2) in adults. However, results suggested that for every 10% increase in daily UPF intake, there was a 19% increase in the risk of CD (RR, 1.19; 95%CI, 1.01-1.32; P = 0.021; I2 = 0.0%; n = 2) among adults. In addition, the results showed a positive linear relation between UPF intake with CD risk (Pnonlinearity = 0.431; Pdose response = 0.049) but not risk of IBD or UC.
Conclusion
High intake of UPFs was linked with an enhanced IBD risk, a specific risk of CD. However, conducting more observational studies among several ethnicities and using specific tools that accurately assess the amount of UPF consumption, components of UPFs, and food additives may be necessary. Systematic Review Registration: PROSPERO registration no. CRD42023390258.
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