Financiado en parte por Ionis Pharmaceuticals, Hass Avocado Board
Untargeted metabolomic analysis investigating links between unprocessed red meat intake and markers of inflammation
Wood AC, Graca G, Gadgil M, Senn MK, Allison MA, Tzoulaki I, Greenland P, Ebbels T, Elliott P, Goodarzi MO, Tracy R, Rotter JI, Herrington D
The American journal of clinical nutrition · 9 citas
Etiquetas de revisión
Vínculos de autores con la industriaCuestionario de frecuencia de consumoFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Empresa
- Ionis Pharmaceuticals
- Gobierno
- National Institutes of Health
- Gobierno
- Agricultural Research Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Grupo de la industria
- Hass Avocado Board
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Agricultural Research Service (58-3092-5-001); National Institute of Diabetes and Digestive and Kidney Diseases (DK063491); National Center for Advancing Translational Sciences (UL1TR001881.); National Institute of Diabetes and Digestive and Kidney Diseases (K23DK119404); National Heart, Lung, and Blood Institute (R01 HL105756)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-09-01 · Am J Clin Nutr · vol. 118 · número 5 · págs. 989–999
- Editorial
- Elsevier BV
- Citado
- 14 citas · más que el 79% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 77 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Meat and Animal Product Quality
- Palabras clave
- Red meat, Glutamine, Inflammation, Fibrinogen, Confounding, C-reactive protein, Metabolomics, Medicine, Internal medicine, Food science, Biology, Amino acid, Biochemistry, Bioinformatics
- MeSH
- humans, inflammation, glutamine, diet, risk factors, cross-sectional studies, meat, aged, middle aged, female, male, red meat
13 autores
- Alexis C. Wood🇺🇸 · autor de correspondenciaChildren's Nutrition Research Center at Baylor College of Medicine
- Gonçalo Graça🇬🇧Imperial College London
- Meghana D. Gadgil🇺🇸University of California, San Francisco
- Mackenzie K. Senn🇺🇸Children's Nutrition Research Center at Baylor College of Medicine
- Matthew Allison🇺🇸University of California San Diego
- Ioanna Tzoulaki🇬🇷University of Ioannina
- Philip Greenland🇺🇸Northwestern University
- Timothy M. D. Ebbels🇬🇧Imperial College London
- Paul Elliott🇬🇧Imperial College London
- Mark O. Goodarzi🇺🇸Cedars-Sinai Medical Center
- Russell P. Tracy🇺🇸University of Vermont
- Jerome I. Rotter🇺🇸UCLA Medical Center; Harbor–UCLA Medical Center
- David M. Herrington🇺🇸Wake Forest University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whether red meat consumption is associated with higher inflammation or confounded by increased adiposity remains unclear. Plasma metabolites capture the effects of diet after food is processed, digested, and absorbed, and correlate with markers of inflammation, so they can help clarify diet-health relationships.
Objective
To identify whether any metabolites associated with red meat intake are also associated with inflammation.
Methods
A cross-sectional analysis of observational data from older adults (52.84% women, mean age 63 ± 0.3 y) participating in the Multi-Ethnic Study of Atherosclerosis (MESA). Dietary intake was assessed by food-frequency questionnaire, alongside C-reactive protein (CRP), interleukin-2, interleukin-6, fibrinogen, homocysteine, and tumor necrosis factor alpha, and untargeted proton nuclear magnetic resonance (1H NMR) metabolomic features. Associations between these variables were examined using linear regression models, adjusted for demographic factors, lifestyle behaviors, and body mass index (BMI).
Results
In analyses that adjust for BMI, neither processed nor unprocessed forms of red meat were associated with any markers of inflammation (all P > 0.01). However, when adjusting for BMI, unprocessed red meat was inversely associated with spectral features representing the metabolite glutamine (sentinel hit: β = -0.09 ± 0.02, P = 2.0 × 10-5), an amino acid which was also inversely associated with CRP level (β = -0.11 ± 0.01, P = 3.3 × 10-10).
Conclusions
Our analyses were unable to support a relationship between either processed or unprocessed red meat and inflammation, over and above any confounding by BMI. Glutamine, a plasma correlate of lower unprocessed red meat intake, was associated with lower CRP levels. The differences in diet-inflammation associations, compared with diet metabolite-inflammation associations, warrant further investigation to understand the extent that these arise from the following: 1) a reduction in measurement error with metabolite measures; 2) the extent that which factors other than unprocessed red meat intake contribute to glutamine levels; and 3) the ability of plasma metabolites to capture individual differences in how food intake is metabolized.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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