Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation
Willmott T, Ormesher L, McBain AJ, Humphreys GJ, Myers JE, Singh G, Lundberg JO, Weitzberg E, Nihlen C, Cottrell EC
Hypertension (Dallas, Tex. : 1979) · 20 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-09-13 · Hypertension · vol. 80 · número 11 · págs. 2397–2406
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 24 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 82 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Sodium Intake and Health · Nitric Oxide and Endothelin Effects · Gut microbiota and health
- Palabras clave
- Nitrate, Nitrite, Blood pressure, Saliva, Medicine, Nitrate reductase, Internal medicine, Oral Microbiome, Endocrinology, Oral administration, Physiology, Animal science, Chemistry, Biology
- MeSH
- humans, bacteria, beta vulgaris, hypertension, nitrates, nitrites, rna, ribosomal, 16s, pregnancy, blood pressure, dietary supplements, adult, female
10 autores
- Thomas Willmott
- Laura Ormesher
- Andrew J. McBain
- Gavin J. Humphreys
- Jenny Myers
- Gurdeep Singh🇬🇧Manchester Academic Health Science Centre
- Jon O. Lundberg🇸🇪Karolinska Institutet
- Eddie Weitzberg🇸🇪Karolinska Institutet
- Carina Nihlén🇸🇪Karolinska Institutet
- Elizabeth C. Cottrell
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The efficacy of dietary nitrate supplementation to lower blood pressure (BP) in pregnant women is highly variable. We aimed to investigate whether differences in oral microbiota profiles and oral nitrate-reducing capacity may explain interindividual differences in BP lowering following nitrate supplementation.
Methods
Participants recruited for this study were both pregnant and nonpregnant women, with or without hypertension (n=55). Following an overnight fast, plasma, saliva, and tongue scraping samples were collected for measurement of nitrate/nitrite concentrations, oral NaR (nitrate reductase) activity, and microbiota profiling using 16S rRNA gene sequencing. Baseline BP was measured, followed by the administration of a single dose of dietary nitrate (400 mg nitrate in 70 mL beetroot juice). Post-nitrate intervention, plasma and salivary nitrate/nitrite concentrations and BP were determined 2.5 hours later.
Results
Women with hypertension had significantly lower salivary nitrite concentrations (P=0.006) and reduced abundance of the nitrate-reducing taxa Veillonella(P=0.007) compared with normotensive women. Oral NaR activity was not significantly different in pregnant versus nonpregnant women (P=0.991) but tended to be lower in hypertensive compared with normotensive women (P=0.099). Oral NaR activity was associated with both baseline diastolic BP (P=0.050) and change in diastolic BP following acute nitrate intake (P=0.01, adjusted for baseline BP).
Conclusions
The abundance and activity of oral nitrate-reducing bacteria impact both baseline BP as well as the ability of dietary nitrate supplementation to lower BP. Strategies to increase oral nitrate-reducing capacity could lower BP and enhance the efficacy of dietary nitrate supplementation, in pregnancy as well as in nonpregnant adults.
Registration
URL: https://www.
Clinicaltrials
gov; Unique identifier: NCT03930693.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.