Association between ultra-processed food consumption and risk of breast cancer: a systematic review and dose-response meta-analysis of observational studies
Shu L, Zhang X, Zhu Q, Lv X, Si C
Frontiers in nutrition · 13 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (82004040)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-09-04 · Front Nutr · vol. 10 · pág. 1250361
- Editorial
- Frontiers Media
- Citado
- 22 citas · más que el 79% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Cancer Risks and Factors
- Palabras clave
- ultra-processed foods, breast cancer, cancer risk, diet and cancer, dose-response relationship, dietary intake
5 autores
- Long Shu🇨🇳Zhejiang Hospital
- Xiaoyan Zhang🇨🇳Zhejiang Hospital
- Qin Zhu🇨🇳Zhejiang Hospital
- Xiaoling Lv🇨🇳Zhejiang Hospital
- Caijuan Si🇨🇳 · autor de correspondenciaZhejiang Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Some epidemiological studies have examined the association between consumption of ultra-processed food (UPF) and the risk of breast cancer. However, the results were inconsistent. Therefore, we carried out a systematic review and dose-response meta-analysis to examine whether an association exists between high consumption of UPF and breast cancer risk.
Methods
PubMed/MEDLINE, ISI Web of Science, EBSCO and CNKI databases were systematically searched from inception to May 2023. The summary relative risks (RRs) and 95% confidence intervals (CIs) associated with UPF consumption and breast cancer were calculated using a random-effects model (DerSimonian-Laird method). Heterogeneity between included studies was examined using the Cochran's Q test and I-square (I2) statistics. Publication bias was studied by visual inspection of funnel plot asymmetry and Begg's and Egger's tests.
Results
Overall, six articles involving 462,292 participants, were eligible to be included in this study. Compared to the lowest consumption, highest consumption of UPF was related to a higher risk of breast cancer (RR = 1.10; 95%CI: 1.00-1.22, p = 0.056). Besides, the linear dose-response analysis showed that each 10% increment in UPF consumption was related to a 5% higher risk of breast cancer (RR = 1.05; 95%CI: 1.00-1.10, p = 0.048). Subgroup analyses suggested that UPF consumption was positively associated with breast cancer risk in case-control studies (RR = 1.13; 95%CI: 1.01-1.26, p = 0.028). Additionally, there was also a significant positive association between UPF consumption and breast cancer risk in the subgroup with sample sizep = 0.028).
Conclusion
Our results indicate that higher consumption of UPF is slightly related to a higher risk of breast cancer. Further studies in particular of large prospective cohort studies are warranted to confirm these results.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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