Financiado en parte por Pfizer, GlaxoSmithKline, Novartis Pharmaceuticals Corporation
Association between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative
Zheng Z, Luo H, Xu W, Shi L, Wang F, Qiu Y, Wang L, Xu Y, Sun C, Xue Q
The journal of nutrition, health & aging · 4 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Health and Human Services
- Empresa
- Pfizer
- Empresa
- GlaxoSmithKline
- Empresa
- Novartis Pharmaceuticals Corporation
- Gobierno
- National Institutes of Health
- Subvenciones
- U.S. Department of Health and Human Services (N01-AR-2-2258); U.S. Department of Health and Human Services (N01-AR-2-2261); U.S. Department of Health and Human Services (N01-AR-2-2262); National Institutes of Health (N01 AR‐2‐2260); Novartis Pharmaceuticals Corporation (N01-AR-2-2261); National Institutes of Health (N01-AR-2-2258); Novartis Pharmaceuticals Corporation (N01-AR-2-2260); U.S. Department of Health and Human Services (N01-AR-2-2259); National Institutes of Health (N01‐AR‐2‐2259); U.S. Department of Health and Human Services (N01-AR-2-2260); National Institutes of Health (N01-AR-2-2261); Pfizer (N01-AR-2-2262); GlaxoSmithKline (N01-AR-2-2262); National Institutes of Health (N01-AR-2-2262)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-09-01 · J Nutr Health Aging · vol. 27 · número 9 · págs. 775–784
- Editorial
- Springer Science+Business Media
- Citado
- 6 citas · más que el 67% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Palabras clave
- Medicine, Confounding, Osteoarthritis, Odds ratio, Prospective cohort study, Body mass index, Cohort study, Internal medicine, Lower risk, Food intake, Physical therapy, Confidence interval
- MeSH
- humans, osteoarthritis, knee, magnesium, risk factors, follow-up studies, prospective studies, dietary fiber, aged, male, frailty
10 autores
- Zitian Zheng🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking University
- Hao Lun Luo🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Wanghong Xu🇨🇳Sun Yat-sen University; Sun Yat-sen Memorial Hospital
- L. Shi🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Fang Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Yan Qiu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Lingling Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Yawei Xu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Chengjun Sun🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Qingyun Xue🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Peking University; Peking Union Medical College Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The objective of this 8-year follow-up study was to investigate the relationship between magnesium intake and frailty, as well as recurrent falls, in individuals diagnosed with Osteoarthritis (OA) or those at a heightened risk for developing the condition.
Methods
This study utilized data from the Osteoarthritis Initiative (OAI) database and conducted a prospective cohort study with a 8-year follow-up period. Total magnesium intake from both food sources and supplements was assessed using a food frequency questionnaire (FFQ), while frailty and recurrent falls were evaluated through established criteria and self-report, respectively. To account for potential confounding factors, various covariates were considered, and statistical analyses, including generalized additive mixed models (GAMMs), were employed to examine the associations.
Results
Among the 4,667 participants with OA, those with lower total magnesium intake were characterized by younger age, a higher proportion of African American individuals, higher body mass index (BMI), and lower dietary fiber intake (P<0.001). Notably, this group exhibited higher odds of experiencing recurrent falls and frailty (P = 0.034 and 0.006, respectively). Controlling for various factors, the GAMMs consistently revealed negative correlations between magnesium intake and the likelihood of frailty and recurrent falls, with each 1 mg/1000 kcal increase in magnesium intake associated with a 0.5% reduced frailty risk (p < 0.001) and a 0.2% decreased risk of recurrent falls (p = 0.001). Subgroup analyses suggested that increased total magnesium intake from both food sources and supplements may exert a more pronounced preventive effect on recurrent falls and frailty in men, older adults, individuals with normal BMI, and those with higher dietary fiber intake.
Conclusions
Elevated total magnesium intake from both food sources and supplements was found to be associated with a decreased risk of recurrent falls and frailty in individuals diagnosed with OA or those at risk of developing the condition. These findings imply that increased total magnesium intake might be beneficial in managing the risk of these outcomes, particularly within specific subgroups, including men, older adults, those with a normal BMI, and those with higher dietary fiber intake.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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