Exploring the differences in serum metabolite profiles after intake of red meat in women with rheumatoid arthritis and a matched control group
Lindqvist HM, Gjertsson I, Hulander E, Bärebring L, Winkvist A
European journal of nutrition · 8 citas
Etiquetas de revisión
Alimentación controladaSolo mecanismosSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Vetenskapsrådet
- Universidad u hospital
- Göteborgs Universitet
- Organización sin fines de lucro
- Magnus Bergvalls Stiftelse
- Gobierno
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Gobierno
- swedish government under the ALF agreement
- Universidad u hospital
- University of Gothenburg
- Subvenciones
- Vetenskapsrådet (2016-01216); Vetenskapsrådet (2021-00954); Magnus Bergvalls Stiftelse (2020-03869); Magnus Bergvalls Stiftelse (2019-03320)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-10-09 · Eur J Nutr · vol. 63 · número 1 · págs. 221–230
- Editorial
- Springer Science+Business Media
- Citado
- 10 citas · más que el 86% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Rheumatoid Arthritis Research and Therapies · Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet
- Palabras clave
- Postprandial, Rheumatoid arthritis, Metabolite, Medicine, Internal medicine, Meal, Red meat, Phenylalanine, Insulin, Biology, Biochemistry
- MeSH
- humans, arthritis, rheumatoid, phenylalanine, case-control studies, research design, female, metabolomics, red meat
5 autores
- Helen M. Lindqvist🇸🇪 · autor de correspondenciaUniversity of Gothenburg
- Inger Gjertsson🇸🇪Sahlgrenska University Hospital; University of Gothenburg
- Erik Hulander🇸🇪University of Gothenburg
- Linnea Bärebring🇸🇪University of Gothenburg
- Anna Winkvist🇸🇪University of Gothenburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Studies have suggested that women with RA tend to avoid red meat more often than women without RA, based on their perception that it exacerbates their symptoms. Therefore, the aim of this study is to investigate and compare the postprandial metabolic response following the consumption of a red meat meal in patients with RA and a matched control group.
Methods
Participants were challenged with a meal with red meat and blood samples were collected before and at 0.5, 1, 2, 3 and 5 h after the meal. Serum metabolites were quantified by Nuclear Magnetic Resonance (NMR) analysis. Orthogonal Projections to Latent Structures with Discriminant Analysis (OPLS-DA) was used to evaluate separation by metabolites due to diagnosis of RA or not and to identify changes in metabolites related to RA. Incremental area under the curve was calculated for univariate comparisons for 23 metabolites.
Results
The matched groups, including 22 women with RA and 22 women without RA, did not differ significantly in age, body mass index, diet quality or reported physical activity. OPLS-DA models had a limited quality indicating that there were no differences in metabolite patterns between the groups. However, phenylalanine was significantly higher in concentration in women with RA compared to controls in both fasting and postprandial samples.
Conclusion
To conclude, this well-controlled postprandial intervention study found a significantly higher concentration of phenylalanine in both fasting and postprandial samples of women with RA compared to matched women without RA. These findings warrant further investigation in larger studies.
Trial registration
The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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