High intake of ultra-processed food is associated with dementia in adults: a systematic review and meta-analysis of observational studies
Henney AE, Gillespie CS, Alam U, Hydes TJ, Mackay CE, Cuthbertson DJ
Journal of neurology · 53 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-10-13 · J Neurol · vol. 271 · número 1 · págs. 198–210
- Editorial
- Springer Science+Business Media
- Citado
- 61 citas · más que el 96% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Sodium Intake and Health
- Palabras clave
- Dementia, Medicine, Observational study, Meta-analysis, Confounding, Confidence interval, Gerontology, Environmental health, Disease, Internal medicine
- MeSH
- humans, dementia, diet, public health, adult, observational studies as topic, food, processed
6 autores
- Alex E. Henney🇬🇧 · autor de correspondenciaUniversity of Liverpool; Aintree University Hospitals NHS Foundation Trust; Aintree University Hospital; Liverpool University Hospitals NHS Foundation Trust
- Conor Scott Gillespie🇬🇧University of Cambridge
- Uazman Alam🇬🇧University of Liverpool; Aintree University Hospitals NHS Foundation Trust; Liverpool University Hospitals NHS Foundation Trust
- Theresa Hydes🇬🇧University of Liverpool; Aintree University Hospitals NHS Foundation Trust; Liverpool University Hospitals NHS Foundation Trust
- Clare E. Mackay🇬🇧University of Oxford
- Daniel James Cuthbertson🇬🇧University of Liverpool; Aintree University Hospitals NHS Foundation Trust; Liverpool University Hospitals NHS Foundation Trust
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Poor cardiometabolic health is associated with dementia. Considering previous meta-analyses have confirmed associations between ultra-processed foods (UPFs) and cardiometabolic disease, we were interested in the contribution of UPF consumption to the risk of developing dementia.
Methods
We performed a systematic review and meta-analysis of all records registered on Ovid Medline and Web of Science from inception until December 2022 [PROSPERO (CRD42023388363)]. Studies that assessed UPF consumption in adults, determined according to NOVA, and that reported dementia (Alzheimer's disease, vascular dementia and mild cognitive impairment) determined by clearly stated diagnostic criteria (including formal assessment of dementia or use of diagnostic codes) were included. The association between UPF consumption and dementia was assessed using random-effects meta-analysis, controlling for confounding variables. Study quality was assessed using the Newcastle Ottawa Scale and evidence credibility evaluated using the NutriGrade system.
Results
Seven thousand ten records were screened, and 122 records underwent full text review. From these, 10 observational (8 longitudinal) studies, analysing 867,316 individuals, were included. Included studies adjusted for age, socioeconomic status and co-morbidity, alongside other confounders. High (vs. low) intake of UPF was associated with increased risk of dementia (pooled relative risk 1.44 (95% confidence interval 1.09-1.90) (p = 0.02)) (I2 = 97.0%), although moderate (vs. low) intake of UPF was not (1.12 (0.96-1.31) (0.13)) (85.0%). Funnel plots demonstrate low risk of publication bias.
Conclusion
High UPF consumption is associated with dementia. Public health measures to reduce overconsumption of UPFs are imperative to reduce the burden of dementia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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