Ketogenic Diet and Multiple Health Outcomes: An Umbrella Review of Meta-Analysis
Chen S, Su X, Feng Y, Li R, Liao M, Fan L, Liu J, Chen S, Zhang S, Cai J, Zhu S, Niu J, Ye Y, Lo K, Zeng F
Nutrients · 32 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Basic and Applied Basic Research Foundation of Guangdong Province
- Gobierno
- Guangdong Basic and Applied Basic Research Foundation
- Universidad u hospital
- Guangdong Provincial Key Laboratory of Food, Nutrition and Health
- Sin clasificar
- Projects of RISA
- Universidad u hospital
- Start-up Fund for New Recruits
- Gobierno
- Natural Science Foundation of Guangdong Province - Youth Enhancement Project
- Subvenciones
- National Natural Science Foundation of China (2022-GLFNH-01); Basic and Applied Basic Research Foundation of Guangdong Province (2022-GLFNH-01); Basic and Applied Basic Research Foundation of Guangdong Province (2023A1515030155); National Natural Science Foundation of China (81602853); Basic and Applied Basic Research Foundation of Guangdong Province (81602853); National Natural Science Foundation of China (2023A1515030155)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-09-27 · Nutrients · vol. 15 · número 19 · pág. 4161
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 39 citas · más que el 97% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 107 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Diet and metabolism studies · Dietary Effects on Health · Nutritional Studies and Diet
- Palabras clave
- ketogenic diet, meta-analyses of meta-analyses, quality of evidence, LDL cholesterol, HDL cholesterol, total cholesterol, respiratory exchange ratio, testosterone, cortisol, physical activity, body weight, seizure reduction
- MeSH
- humans, seizures, testosterone, treatment outcome, cross-sectional studies, reproducibility of results, child, cholesterol, ldl, meta-analysis as topic, drug resistant epilepsy, multimorbidity, diet, ketogenic
15 autores
- Shiyun Chen🇨🇳Jinan University
- Xin Bing Su🇨🇳Jinan University
- Yonghui Feng🇨🇳Jinan University
- Ruo-Jie Li🇨🇳Jinan University
- Minqi Liao🇩🇪Helmholtz Munich
- Laina Fan🇨🇳Jinan University
- Jiazi Liu🇨🇳Jinan University
- Shasha Chen🇨🇳Jinan University
- Shiwen Zhang🇨🇳Jinan University
- Jun Cai🇨🇳Jinan University
- Sui Zhu🇨🇳Jinan University
- Jianxiang Niu🇨🇳Inner Mongolia Medical University
- Yanbin Ye🇨🇳Jinan University; First Affiliated Hospital of Jinan University
- Kenneth Ka-Hei Lo🇭🇰 · autor de correspondenciaHong Kong Polytechnic University
- Fangfang Zeng🇨🇳 · autor de correspondenciaJinan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Numerous studies have examined the effects of ketogenic diets (KD) on health-related outcomes through meta-analyses. However, the presence of biases may compromise the reliability of conclusions. Therefore, we conducted an umbrella review to collate and appraise the strength of evidence on the efficacy of KD interventions. We conducted a comprehensive search on PubMed, EMBASE, and the Cochrane Database until April 2023 to identify meta-analyses that investigated the treatment effects of KD for multiple health conditions, which yielded 23 meta-analyses for quantitative analyses. The evidence suggests that KD could increase the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), the respiratory exchange rate (RER), and could decrease total testosterone and testosterone levels (all p-random effects: <0.05). The combination of KD and physical activity can significantly reduce body weight and increase the levels of LDL-C and cortisol. In addition, KD was associated with seizure reduction in children, which can be explained by the ketosis state as induced by the diet. Furthermore, KD demonstrated a better alleviation effect in refractory childhood epilepsy, in terms of median effective rates for seizure reduction of ≥50%, ≥90%, and seizure freedom. However, the strength of evidence supporting the aforementioned associations was generally weak, thereby challenging their credibility. Consequently, future studies should prioritize stringent research protocols to ascertain whether KD interventions with longer intervention periods hold promise as a viable treatment option for various diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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