The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis
Turner L, Charrouf R, Martínez-Vizcaíno V, Hutchison A, Heilbronn LK, Fernández-Rodríguez R
The American journal of clinical nutrition · 37 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Adelaide
- Gobierno
- Ministerio de Educación, Cultura y Deporte
- Subvenciones
- Ministerio de Educación, Cultura y Deporte (FPU 19/00167)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-10-20 · Am J Clin Nutr · vol. 119 · número 1 · págs. 206–220
- Editorial
- Elsevier BV
- Citado
- 46 citas · más que el 90% de estudios similares · 2.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 72 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Nutritional Studies and Diet
- Palabras clave
- time-restricted eating, inflammatory cytokines, adipokines, C-reactive protein, TNF-α, interleukin-6, leptin, adiponectin, inflammation, obesity, weight loss, habitual diet, adults, sleep timing, meal timing, energy intake, energy expenditure, physical activity
- MeSH
- humans, inflammation, leptin, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, cytokines, diet, adult, adiponectin, adipokines
6 autores
- Laurent Turner🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Rasha Charrouf🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Vicente Martínez‐Vizcaíno🇨🇱🇪🇸Universidad Autónoma de Chile; University of Castilla-La Mancha
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
- Rubén Fernández‐Rodríguez🇦🇺🇪🇸South Australian Health and Medical Research Institute; The University of Adelaide; University of Castilla-La Mancha
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted eating (TRE) may facilitate weight loss, but its impact on inflammation remains unclear. Chronic inflammation can detrimentally increase risk of obesity-associated comorbidities.
Objectives
The aim of this systematic review was to synthesize and determine the effects of TRE on cytokine and adipokines (C-reactive protein [CRP], TNF alpha [TNF-α], interleukin-6 [IL-6], leptin, and adiponectin) in adults.
Methods
PubMed, Scopus, Cochrane CENTRAL, and Web of Science were systematically searched for randomized controlled trials (RCTs) and non-RCTs to determine the effects of TRE on cytokines and adipokines in adults up to 23 June, 2023. Risk of bias was assessed using risk of Bias 2 tool for RCTs and the ROBINS-I for non-RCTs. The standardized mean differences (SMDs) and their 95% confidence intervals (CIs) were estimated with the DerSimonian-Laird method through random-effect models. The PRISMA recommendations were followed.
Results
A total of 25 studies (13 RCTs, 12 non-RCTs) involving 936 participants were included. The pooled SMD for the effect of TRE compared with the control group on cytokines and adipokines was -0.11 (95% CI: -0.33, 0.12; I2 = 19.7%; n = 10 comparisons) for CRP; -0.25 (95% CI: -0.47, -0.03; I2 = 0%; n = 11 comparisons) for TNF-α; -0.09 (95% CI: -0.39, 0.21; I2 = 16.4%; n = 8 comparisons) for IL-6; -0.81 (95% CI: -1.37, -0.24; I2 = 65.3%; n = 5 comparisons) for leptin; and 0.07 (95% CI: -0.40, 0.54; I2 = 56.9%; n = 6 comparisons) for adiponectin.
Conclusions
Time-restricted eating may be an effective approach to reduce TNF-α and leptin levels in the general adult population. This review was registered at PROSPERO as CRD42022358162.
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