High Intake of Dietary Cholesterol Decreases the Risk of All-Cause Dementia and AD Dementia: A Results from Framingham Offspring Cohort
Wang M, Wang Y, Zhang Y, Zhang W, Wang Y, Fan R, Wen Y
The journal of prevention of Alzheimer's disease · 5 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciación no declaradaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-05-25 · J Prev Alzheimers Dis · vol. 10 · número 4 · págs. 748–755
- Editorial
- Springer Science+Business Media
- Citado
- 4 citas · más que el 74% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nutritional Studies and Diet · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- Dementia, Medicine, Framingham Heart Study, Offspring, Interquartile range, Cohort study, Cohort, Internal medicine, Diabetes mellitus, Cholesterol, Stroke (engine), Prospective cohort study, Framingham Risk Score, Gerontology, Endocrinology, Disease, Pregnancy, Biology
- MeSH
- humans, dementia, alzheimer disease, cholesterol, dietary, risk factors, prospective studies, middle aged
7 autores
- Mingmin Wang🇨🇳First People's Hospital of Chongqing
- Yanqiu Wang
- Yuzhu Zhang
- Weipeng Zhang
- Youjie Wang
- Ruitai Fan
- Yubing Wen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary cholesterol has been confirmed to be associated with high risks of diabetes, hypertension, and stroke, but whether it is detrimental to cognitive health is highly debated. This study aimed to investigate the associations between dietary cholesterol and all-cause dementia and AD dementia.
Methods
This prospective study analyzed Framingham Offspring Study cohort (FOS) participants who were dementia-free at baseline and had detailed information on daily diet (measured by food frequency questionnaires) and demographic characteristics. Surveillance for incident dementia commenced at examination 5 (1991-1995) through 2018 and continued for approximately 30 years.
Results
A total of 3249 subjects were included with a mean age of 54.7 years (SD: 9.8). During a median follow-up of 20.2 years (interquartile range: 14.2-24.8), a total of 312 incident dementia events occurred, including 211 (67.7%) cases of AD dementia. After multivariate adjustments for established dementia risk factors, participants with the highest intake of dietary cholesterol had a lower risk of all-cause dementia (HR: 0.70; 95% CI: 0.57-0.93) and AD dementia (HR: 0.68; 95% CI: 0.60-0.88) relative to individuals with the lowest intake. However, the associations were not significant for the group with a medium intake of dietary cholesterol.
Conclusion
High intake of dietary cholesterol was associated with a decreased risk of all-cause dementia and AD dementia. The findings of this observational study need to be confirmed by other studies to highlight the role of dietary cholesterol in the development of neurodegenerative diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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