Broccoli-Derived Exosome-like Nanoparticles Alleviate Loperamide-Induced Constipation, in Correlation with Regulation on Gut Microbiota and Tryptophan Metabolism
Duan T, Wang X, Dong X, Wang C, Wang L, Yang X, Li T
Journal of agricultural and food chemistry · 49 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Gobierno
- National Natural Science Foundation of China
- Grupo de la industria
- Young Talent Fund of Association for Science and Technology in Shaanxi, China
- Gobierno
- Youth Star of Science and Technology in Shaanxi Province
- Universidad u hospital
- National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China
- Subvenciones
- National Natural Science Foundation of China (32272309)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2023-10-24 · J Agric Food Chem · vol. 71 · número 44 · págs. 16568–16580
- Editorial
- American Chemical Society
- Citado
- 65 citas · más que el 99% de estudios similares · 12.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gastrointestinal motility and disorders · Gut microbiota and health · Congenital gastrointestinal and neural anomalies
- Palabras clave
- Gut flora, Tryptophan, Feces, Constipation, Biology, Pharmacology, Biochemistry, Chemistry, Microbiology, Internal medicine, Medicine
- MeSH
- animals, humans, mice, brassica, constipation, loperamide, tryptophan, rna, ribosomal, 16s, neurotransmitter agents, nanoparticles, exosomes, gastrointestinal microbiome
7 autores
- Tianchi Duan🇨🇳Shaanxi Normal University
- Xiaoyuan Wang🇨🇳Shaanxi Normal University
- Xinyue Dong🇨🇳Shaanxi Normal University
- Chennan Wang🇨🇳Shaanxi Normal University
- Lu Wang🇨🇳Shaanxi Normal University
- Xingbin Yang🇨🇳Shaanxi Normal University
- Ting Li🇨🇳 · autor de correspondenciaShaanxi Normal University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Constipation, a common gastrointestinal dysfunction, damages patients' life quality and predisposes them to other serious diseases. Current strategies against constipation often cause drug dependency and side effects. Here, we demonstrated that broccoli-derived exosome-like nanoparticles (BENs), a natural product with high gastrointestinal stability, ameliorated LOP-induced constipation in mice. Specifically, orally administered BENs (17.5 mg/kg/d) effectively shortened defecation time, sped up intestinal propulsion rate, and increased feces amount in constipated mice. BENs also raised excitatory neurotransmitters SP and MTL and reduced inhibitory neurotransmitters VIP and ET-1. Mechanistically, BENs were taken up by gut microbes, restored LOP-disordered gut microbiota, and altered microbial metabolism of SCFAs and tryptophan, as evidenced by the results of fluorescence microscopy, 16S rRNA gene sequencing, and nontargeted metabolomics. Thereinto, BEN-enriched SCFA-producing microorganisms are closely associated with the feces amount and SP and VIP levels and BEN-elevated indole-3-pyruvic acid and 3-indoleacetic acid are highly linked to ET-1, SP, and MTL levels. Conclusively, BENs, mitigating constipation by regulating gut microbiota and microbial tryptophan metabolism, showed high potential to be developed as alternative regimens for constipation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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