A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study
Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L
Journal of integrative and complementary medicine · 18 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-10-25 · J Integr Complement Med · vol. 30 · número 5 · págs. 459–468
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 24 citas · más que el 97% de estudios similares · 7.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Andrographolide Research and Applications
- Palabras clave
- Placebo, Piperine, Medicine, Withania somnifera, Repeated measures design, Hamilton Anxiety Rating Scale, Anxiety, Randomized controlled trial, Internal medicine, Traditional medicine, Pharmacology, Psychiatry
- MeSH
- humans, withania, plant roots, serotonin, alkaloids, piperidines, plant extracts, phytotherapy, double-blind method, depression, anxiety, quality of life, adult, middle aged, female, male, benzodioxoles, polyunsaturated alkamides, young adult
6 autores
- Muhammed A. Majeed🇺🇸Sabin Vaccine Institute
- Kalyanam Nagabhushanam🇺🇸Sabin Vaccine Institute
- Avinash Murali
- Devarajan T Vishwanathan🇮🇳Apollo Hospitals; Apollo Hospitals
- Ramamohan V Mamidala🇮🇳Narayana Dental College and Hospital
- Lakshmi Mundkur · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Withania somnifera (Linn) or Ashwagandha is used in Ayurveda and other traditional medicine systems as an adaptogen and a neuroprotective supplement. Objective: The effect of Ashwagandha root extract (ARE) standardized for 2.5% full-spectrum withanolides as per The United States Pharmacopeia (USP) protocol with piperine (500 mg with 5 mg of 95% piperine) once a day (12.5 mg withanolides/day) was evaluated in individuals with mild to moderate depression and anxiety. Methods: In a randomized, double-blind placebo-controlled study, for 90 days, 70 participants were randomized to ARE (n = 34) or placebo (n = 36) once daily at night. Mean change in the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS), Groningen Sleep Quality Scale (GSQS), and quality of life (QOL) from screening to days 30, 60, and 90 were evaluated. Safety was evaluated by monitoring any incidence of adverse events and laboratory parameters. Two-way analysis of variance (ANOVA) and repeated-measure ANOVA were used to compare ARE and placebo, and the changes within the group at different time points. Results: Seventy individuals were randomized and all of them completed the study. The HARS, HDRS, GSQS, and QOL scores improved significantly (p p Conclusion: The results of the study suggest that 500 mg of ARE standardized for 2.5% withanolides with 5 mg piperine is beneficial in improving depression, and anxiety, by increasing serum serotonin levels. The trial was registered prospectively with the Clinical Trial Registry of India (CTRI) with the registration number CTRI/2022/05/042640, on May 18, 2022.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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