Buccopharyngeal route administered high polyphenolic olive oil and COVID-19: A pilot clinical trial
Rodríguez-Argente F, Alba-Domínguez M, Díaz-Martínez MP, Díaz-Vergara C, Díaz-Márques B, Ferrero-Ortega P, Gil-Adrados AC, Gómez-Bernardo L, Gordo-Murillo L, Fuente EH, Jurado-Palomo J, Ortega-González Á, Machado-Gallas J, Moreno-Ancillo Á, Ávila-Martín G, Marín-Guerrero AC, Álvarez-Gregori J
Immunity, inflammation and disease · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-10-01 · Immun Inflamm Dis · vol. 11 · número 10 · pág. e1054
- Editorial
- Wiley
- Citado
- 3 citas · más que el 66% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- COVID-19 Clinical Research Studies · SARS-CoV-2 and COVID-19 Research · Edible Oils Quality and Analysis
- Palabras clave
- COVID-19 pandemic, SARS-CoV-2, olive oil, polyphenols, immunomodulation, mucosal immunity, symptom duration, symptom severity, COVID-19 incidence, vaccine waning, dietary supplementation, SARS-CoV-2 variants
- MeSH
- humans, treatment outcome, time factors, adult, olive oil, covid-19, sars-cov-2
17 autores
- Francisco Rodríguez‐Argente🇪🇸 · autor de correspondenciaHospital General Nuestra Señora del Prado
- María Alba‐Domínguez
- María P. Díaz‐Martínez🇪🇸Hospital General Nuestra Señora del Prado
- Cristian Díaz‐Vergara🇪🇸Hospital General Nuestra Señora del Prado
- Belén Díaz‐Márques🇪🇸Hospital General Nuestra Señora del Prado
- Paloma Ferrero‐Ortega🇪🇸Hospital General Nuestra Señora del Prado
- A.C. Gil-Adrados🇪🇸Hospital General Nuestra Señora del Prado
- Lorena Gómez‐Bernardo🇪🇸Hospital General Nuestra Señora del Prado
- Laura Gordo‐Murillo🇪🇸Hospital General Nuestra Señora del Prado
- Elsa Humanes de la Fuente🇪🇸Hospital General Nuestra Señora del Prado
- Jesús Jurado Palomo🇪🇸Hospital General Nuestra Señora del Prado
- Ángel Ortega González🇪🇸Hospital General Nuestra Señora del Prado
- Juana María Machado-Gallas🇪🇸Hospital General Nuestra Señora del Prado
- Álvaro Moreno‐Ancillo🇪🇸Hospital General Nuestra Señora del Prado
- Gerardo Ávila-Martín🇪🇸Hospital General Nuestra Señora del Prado
- Ana Cecilia Marín Guerrero🇪🇸Hospital General Nuestra Señora del Prado
- Joaquín Álvarez Gregori🇪🇸Hospital General Nuestra Señora del Prado
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Waning immunity after vaccination justifies the need for additional effective COVID-19 treatments. Immunomodulation of local immune response at the oropharyngeal mucosa could hypothetically activate mucosal immunity, which can prevent SARS-CoV-2 main immune evasion mechanisms in early stages of the disease and send an effective warning to other components of immune system. Olive polyphenols are biologically active compounds with immunomodulatory activity. There are previous studies based on immunomodulation with olive polyphenols and respiratory infections using an enteral route, which point to potential effects on time to resolution of symptoms. The investigators sought to determine whether participants following immunomodulation with tiny quantities of high polyphenolic olive oil administered through an oromucosal route could have a better outcome in COVID-19.
Summary
This pilot clinical trial investigated the effect of buccopharyngeal administered high polyphenolic olive oil on COVID-19 incidence, duration, and severity.
Importance
Waning immunity after vaccination justifies the need of further research for additional effective treatments for COVID-19.
Objective
Immunomodulation of local immune response at the buccopharyngeal mucosa could hypothetically activate mucosal immunity, which would in turn difficult SARS-CoV-2 immune evasion mechanisms in early stages of the disease and send an effective warning to other components of immune system. Olive polyphenols are biologically active compounds with immunomodulatory activity. There are previous studies based on immunomodulation with olive polyphenols and respiratory infections, using an enteral route, which suggest potential shortening of time to resolution of symptoms. The investigators sought to determine whether participants following immunomodulation with tiny quantities of high polyphenolic olive oil administered through an oromucosal route could have a better outcome in COVID-19.
Design, setting, and participants
Double blind, randomized pilot clinical trial conducted at a single site, Talavera de la Reina, Spain. Potential study participants were identified by simple random sampling from the epidemiological database of contact patients recently diagnosed of COVID-19 during the study period. A total of 88 adult participants were enrolled and 84 completed the 3-month study, conducted between July 1, 2021 and August 31, 2022.
Intervention
Participants were randomized to receive oromucosal administered high polyphenolic olive oil, 2 mL twice a day for 3 months or no treatment.
Main outcome and measures
Primary outcomes were incidence, duration, and severity of COVID-19 after intervention.
Results
There were no differences in incidence between both groups but there were significant differences in duration, the median time to resolution of symptoms was 3 days in the high polyphenolic olive oil group compared with 7 days in the no-treatment group. Although time to resolution is directly related to severity, this study did not find any differences in severity.
Conclusion and relevance
Among full-vaccinated adults recent infected with COVID-19, a daily intake of tiny quantities of oromucosal administered high polyphenolic olive oil before infection significantly improved the time to symptom resolution. This finding strongly support the appropriateness of further deep research on the use of oromucosal administered high polyphenolic olive oil as an effective immune strategy against COVID-19.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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