Effects of dietary nitrate and vitamin C co-ingestion on blood pressure and hand-grip strength in young adults
Lbban E, Macey A, Rundle J, Ashor A, Idris I, Siervo M
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 5 citas
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Quién lo pagó
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Publicación
- Publicado
- 2023-11-08 · Int J Vitam Nutr Res · vol. 94 · número 5-6 · págs. 342–353
- Editorial
- Hogrefe Verlag
- Citado
- 7 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology
- Palabras clave
- dietary nitrate, inorganic nitrate, vitamin C, beetroot juice, blood pressure, grip strength, vascular function, oxidative stress, nitrite, 8-isoprostane, salivary nitrate, urinary nitrate, young adults, cardiovascular health
- MeSH
- saliva, humans, beta vulgaris, nitrates, ascorbic acid, hand strength, cross-over studies, double-blind method, blood pressure, dietary supplements, adult, female, male, young adult, fruit and vegetable juices
6 autores
- Eazaz Lbban🇬🇧🇸🇦University of Nottingham; Umm al-Qura University; Queen's Medical Centre
- Alex Macey🇬🇧University of Nottingham; Queen's Medical Centre
- Joshua Rundle🇬🇧University of Nottingham; Queen's Medical Centre
- Ammar Waham Ashor🇮🇶Mustansiriyah University
- ISKANDAR RAUF IDRIS🇬🇧University of Nottingham
- Mario Siervo🇬🇧🇦🇺University of Nottingham; Curtin University; Queen's Medical Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Co-administration of vitamin C and inorganic nitrate ([Formula: see text]) may reduce oxidative stress, boost the conversion of nitrite ([Formula: see text]) into NO and elicit positive vascular effects. Aims: We aimed to test the effects of oral inorganic [Formula: see text] and vitamin C co-supplementation on vascular function, muscular strength, and on concentrations of urinary [Formula: see text], vitamin C, 8-isoprostanes and salivary [Formula: see text] in healthy young adults. Methods: Ten young healthy participants were enrolled in a randomised, double-blind (only for the [Formula: see text] intervention) crossover clinical trial. Participants consumed in random order: 1) nitrate-rich beetroot juice and vitamin C (N+VC), 2) nitrate-rich beetroot juice alone (N) or 3) nitrate-depleted beetroot juice alone (ND). Resting blood pressure (BP) was measured at the research centre and at home. Non-invasive, continuous measurements of BP and cardiac function parameters were performed using a Finometer device. Free-living physical activity and hand-grip strength were assessed. Salivary [Formula: see text] and [Formula: see text] and urinary [Formula: see text], 8-isoprostanes and vitamin C concentrations were measured. Results: There were no significant differences for any of the vascular outcomes between the three interventions groups. However, analyses of within-intervention changes showed a significant lower daily systolic BP in the [Formula: see text]+vitamin C (N+VC) group only (P=0.04). Urinary [Formula: see text] (P=0.002) and salivary [Formula: see text] (P=0.001) were significantly higher in the N+VC group compared to the N and ND groups. Conclusion: These preliminary findings suggest that combining dietary [Formula: see text] with vitamin C could have protective effects on vascular function in young adults and could represent an effective strategy for the maintenance of healthy cardiovascular trajectories.
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