Financiado en parte por Egg Nutrition Center
The Impact of Whole Egg Consumption on Bone Accrual in Healthy Children: A Randomized Controlled Trial
Coheley LM, Yu M, Chen X, O'Connor PJ, Kealey KS, Laing EM, Oshri A, Marand AK, Lance JM, Kindler JM, Lewis RD
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1 cita
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Egg Nutrition Center
- Gobierno
- National Institute on Aging
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIA NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (KL2-TR-002381); National Center for Advancing Translational Sciences (UL1TR002378); National Institute on Aging (U54AG062334)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-11-11 · J Bone Miner Res · vol. 38 · número 12 · págs. 1809–1821
- Editorial
- Oxford University Press
- Citado
- 3 citas · más que el 64% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Bone health and osteoporosis research · Birth, Development, and Health · Nutrition and Health in Aging
- Palabras clave
- Medicine, Micronutrient, Bone mineral, Randomized controlled trial, Quantitative computed tomography, Cortical bone, Tibia, Vitamin D and neurology, Bone density, Placebo, Osteoporosis, Dentistry, Internal medicine, Surgery, Anatomy, Pathology
- MeSH
- bone and bones, lumbar vertebrae, humans, minerals, gelatin, absorptiometry, photon, bone density, child, child, preschool, female, male, randomized controlled trials as topic
11 autores
- Lauren M. Coheley🇺🇸 · autor de correspondenciaTexas A&M University
- Mengyun Yu🇺🇸University of Georgia
- Xianyan Chen🇺🇸University of Georgia
- Patrick J. O’Connor🇺🇸University of Georgia
- Kirk S. Kealey🇺🇸University of Georgia
- Emma M. Laing🇺🇸University of Georgia
- Assaf Oshri🇺🇸University of Georgia
- Alicia K. Marand🇺🇸University of Georgia
- Julia M. Lance🇺🇸University of Georgia
- Joseph M. Kindler🇺🇸University of Georgia
- Richard D. Lewis🇺🇸University of Georgia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary interventions designed to examine the role of nutrition on childhood bone accrual have often focused on the role of individual micronutrients (eg, calcium, vitamin D, and zinc) and macronutrients (eg, protein). The osteogenic benefits of whole foods, such as eggs, are not well understood despite eggs being a source of high-quality nutrients and bioactive compounds known to positively influence bone. A significant positive cross-sectional association between whole egg consumption and tibia cortical bone mass has recently been shown in young children; however, randomized controlled trials (RCTs) have not been conducted. This study is a double-blind RCT in male and female children ages 9-13 years of different ancestries, designed to determine if consuming food products with whole eggs (equivalent to 8-10 eggs/wk) versus foods with milk or gelatin (placebo) over a 9-month period will improve measures of bone strength. Total body less head (TBLH) and lumbar spine bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed using dual-energy X-ray absorptiometry (DXA). DXA Z-scores were computed using published pediatric growth charts and were adjusted for height-for-age Z-score (HAZ). Mid-tibia cortical volumetric BMD, BMC, cortical area, total bone area, cortical thickness, and strength strain index were measured using peripheral quantitative computed tomography. Overall, there were no significant intervention effects for any bone outcomes. The increase in spine BMCHAZ Z-score in the egg group versus the gelatin group approached significance (p = 0.07). Significant time effects in TBLH aBMDHAZ Z-score occurred as all groups decreased over 9 months (p < 0.03). Most tibia cortical bone outcomes increased over time (all p < 0.02), but changes did not differ across intervention groups. Whole eggs provide important nutritional benefits for children, but the bone responses to consumption of 8-10 eggs/wk over a period of 9 months in children entering the early stages of puberty were small. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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