The effects of blueberry and cranberry supplementation on blood pressure in patients with cardiovascular diseases: A systematic review and meta-analysis of randomized clinical trials
Delpino FM, Dos Santos FS, Flores TR, Cerqueira HS, Santos HO, Santos HO
Phytotherapy research : PTR · 8 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- National Council for Scientific and Technological Development (CNPq)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-11-14 · Phytother Res · vol. 38 · número 2 · págs. 646–661
- Editorial
- Wiley
- Citado
- 7 citas · más que el 55% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 82 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Blood Pressure and Hypertension Studies · Pharmacology and Obesity Treatment · Consumer Attitudes and Food Labeling
- Palabras clave
- Meta-analysis, Medicine, Randomized controlled trial, Blood pressure, Confidence interval, CRANBERRY JUICE, Internal medicine, Clinical trial, Traditional medicine
- MeSH
- humans, vaccinium macrocarpon, fruit, cardiovascular diseases, blood pressure, dietary supplements, randomized controlled trials as topic, blueberry plants
5 autores
- Felipe Mendes Delpino🇧🇷 · autor de correspondenciaUniversidade Federal de Pelotas
- Francine Silva dos Santos🇧🇷Universidade de São Paulo
- Thaynã Ramos Flores🇧🇷Universidade Federal de Pelotas
- Henrique Santa Capita Cerqueira🇧🇷Universidade de São Paulo
- Heitor Oliveira Santos🇧🇷Universidade Iguaçu
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberries and cranberries are berry fruits with the highest number of randomized clinical trials (RCTs) focusing on blood pressure (BP). This systematic review and meta-analysis of RCTs analyzed the effects of blueberry and cranberry supplementation alone and in concert with systolic BP (SBP) and diastolic BP (DBP) in patients with cardiometabolic diseases. The searches were performed until August 2023 in the following databases: PubMed, Scopus, Web of Science, Cochrane, and Embase. Studies that examined the effects of blueberry or cranberry intake/supplementation were included. The risk of bias was evaluated using the Rob 2 scale. A meta-analysis was performed to estimate the effects of blueberry and cranberry supplementation on BP levels in patients with cardiometabolic diseases. A total of 17 articles were included, from which two found significant results from blueberry and/or cranberry supplementation in reducing BP. Pooled results revealed statistically non-significant reductions of -0.81 mm Hg for SBP (95% confidence interval [CI]: -2.26, 0.63; I2 = 0%) and -0.15 mm Hg for DBP (95% CI: -1.36, 1.05; I2 = 27%). Blueberry and/or cranberry supplementation had neutral effects on SBP and DBP in patients with cardiometabolic diseases, regardless of duration or age. Further high-quality studies are needed to firmly establish clinical efficacy.
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