The Short-Term Effect of Olive Oil Extract Enriched with Hydroxytyrosol on Cardiovascular Function
Iakovis N, Ikonomidis I, Andreadou I, Xanthopoulos Α, Chamaidi A, Chrysakis N, Giamouzis G, Skoularigis J, Tseti I, Triposkiadis F
Journal of medicinal food · 5 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-11-15 · J Med Food · vol. 26 · número 12 · págs. 939–942
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 6 citas · más que el 80% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 15 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Edible Oils Quality and Analysis · Cardiovascular Function and Risk Factors
- Palabras clave
- olive oil extract, hydroxytyrosol, stable coronary artery disease, left ventricular diastolic function, left atrial function, arterial stiffness, pulse wave velocity, aortic elasticity, polyphenols, antioxidant supplementation, cardiovascular function
- MeSH
- humans, ventricular dysfunction, left, phenylethyl alcohol, echocardiography, doppler, ventricular function, left, aged, pulse wave analysis, olive oil
10 autores
- Nikolaos Iakovis🇬🇷University Hospital of Larissa
- Ignatios Ikonomidis🇬🇷University General Hospital Attikon
- Ioanna Andreadou🇬🇷National and Kapodistrian University of Athens
- Andrew V. Xanthopoulos🇬🇷University Hospital of Larissa
- Aikaterini Chamaidi🇬🇷University Hospital of Larissa
- Nikolaos Chrysakis🇬🇷University Hospital of Larissa
- Grigorios Giamouzis🇬🇷University Hospital of Larissa
- John S. Skoularigis🇬🇷University Hospital of Larissa
- Ioulia K. Tseti
- Filippos K. Triposkiadis🇬🇷 · autor de correspondenciaUniversity Hospital of Larissa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Olive is rich in polyphenols such as hydroxytyrosol (HT) that have antioxidative and anti-inflammatory effects. In this study, we examined the short-term effects of olive oil extract (OE) enriched with HT on left atrial function, left ventricular (LV) function, and arterial elastic properties in patients with chronic coronary artery disease (CAD). Sixty-one patients with chronic CAD were enrolled. This randomized study had a two-period, two-sequence crossover (AB/BA) design. Group AB (n = 32) initially received OE capsules (500 mg) enriched with HT (5 mg) (two capsules/day) for 30 days, and after a wash out of 48 h, placebo for another 30 days. The opposite occurred in Group BA (n = 29). Exclusion criteria included age >70 years, diabetes, anemia, hypertension, liver and thyroid disease, malignancy, autoimmune disease, kidney disease, use of corticosteroids, weight loss, excessive exercise dietary intervention, and use of antioxidant vitamins. Patients underwent echocardiography/Doppler and applanation tonometry applied to radial artery at the beginning and end of the study. No significant change regarding Vmax, Vp, Vmin, E wave, A wave, deceleration time, LV ejection fraction, central aortic systolic and pulse pressure, and augmentation index. However, a trend toward improvement of E/e' (P = .062) and pulse wave velocity (P = .091) was observed. Use of OE enriched with HT for a limited time period was associated with a trend toward improvement of LV diastolic function and aortic elastic properties in chronic CAD patients. Studies of longer duration are needed to delineate the effect of this promising agent on cardiovascular function and outcomes in chronic CAD.
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