Low-Density-Lipoprotein Cholesterol and Mortality Outcomes Among Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Zhou Z, Tonkin AM, Curtis AJ, Murray A, Zhu C, Reid CM, Williamson JD, Ryan J, McNeil JJ, Beilin LJ, Ernst ME, Stocks N, Lacaze P, Shah RC, Woods RL, Wolfe R, Gall S, Zoungas S, Orchard SG, Nelson MR
The journals of gerontology. Series A, Biological sciences and medical sciences · 10 citas
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Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Gobierno
- Victorian Cancer Agency
- Organización sin fines de lucro
- Royal Australian College of General Practitioners
- Universidad u hospital
- Monash University
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Gobierno
- National Institute on Aging
- Gobierno
- National Cancer Institute
- Empresa
- Royal Australian College of General Practitioners (RACGP)/HCF Research Foundation Research
- Gobierno
- NIA NIH HHS
- Gobierno
- NIH HHS
- Gobierno
- NCI NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Cancer Institute (U19AG062682); National Cancer Institute (1127060); National Institutes of Health (1127060); National Institute on Aging (P30-AG024824); National Health and Medical Research Council (1127060); National Institute on Aging (U01 AG029824); National Cancer Institute (U01AG029824); National Cancer Institute (334047); National Institute on Aging (U19 AG062682); National Institutes of Health (334047); National Health and Medical Research Council (334047); National Institutes of Health (U19 AG062682); National Institutes of Health (U01 AG029824)
Según 12 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-12-01 · J Gerontol A Biol Sci Med Sci · vol. 79 · número 4
- Editorial
- Oxford University Press
- Citado
- 14 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- LDL cholesterol, mortality, older adults, cardiovascular mortality, cancer mortality, all-cause mortality, U-shaped relationship, ASPREE trial, healthy aging, sex differences
- MeSH
- humans, neoplasms, cardiovascular diseases, cholesterol, lipoproteins, risk factors, aged, male, cholesterol, ldl, cholesterol, hdl
20 autores
- Zhen Zhou🇦🇺 · autor de correspondenciaUniversity of Tasmania; Menzies Institute for Medical Research; Monash University
- Andrew Maxwell Tonkin🇦🇺Monash University
- Andrea J. Curtis🇦🇺Monash University
- Anne M. Murray🇺🇸University of Minnesota; Berman Center for Outcomes and Clinical Research; Hennepin Healthcare Research Institute
- Chao Zhu🇦🇺Monash University
- Christopher Michael Reid🇦🇺Curtin University
- Jeff D. Williamson🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Joanne L. Ryan🇦🇺Monash University
- John J. McNeil🇦🇺Monash University
- Lawrence Joseph Beilin🇦🇺The University of Western Australia; Royal Perth Hospital
- Michael E. Ernst🇺🇸University of Iowa
- Nigel Stocks🇦🇺The University of Adelaide
- Paul A Lacaze🇦🇺Monash University
- Raj C. Shah🇺🇸Rush University Medical Center
- Robyn L. Woods🇦🇺Monash University
- Rory S Wolfe🇦🇺Monash University
- Seana Gall🇦🇺University of Tasmania; Menzies Institute for Medical Research
- Sophia Zoungas🇦🇺Monash University
- Suzanne Gaye Orchard🇦🇺Monash University
- Mark Raymond Nelson🇦🇺 · autor de correspondenciaUniversity of Tasmania; Menzies Institute for Medical Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The prognostic implication of cholesterol levels in older adults remains uncertain. This study aimed to examine the relationship between low-density-lipoprotein cholesterol (LDL-c) and mortality outcomes in older individuals.
Methods
This post hoc analysis examined the associations of LDL-c levels with mortality risks from all-cause, cardiovascular disease (CVD), cancer, and combined non-CVD/noncancer conditions in a cohort of individuals aged ≥65 years from the ASPirin in Reducing Events in the Elderly trial (NCT01038583). At baseline, participants had no diagnosed dementia, physical disability, or CVD, and were not taking lipid-lowering agents. Outcome analyses were performed using multivariable Cox models.
Results
We analyzed 12 334 participants (mean age: 75.2 years). Over a median 7-year follow-up, 1 250 died. Restricted cubic splines found a U-shaped relation for LDL-c and all-cause mortality, cancer mortality, and noncancer/non-CVE mortality (nadir: 3.3-3.4 mmol/L); the risk of CVD mortality was similar at LDL-c below 3.3 mmol/L and increased above 3.3 mmol/L. Similar trends were observed in analyses modeling LDL-c by quartiles. When modeling LDL-c as a continuous variable, the risk of all-cause mortality, cancer mortality, and noncancer/non-CVD mortality was decreased by 9%, 16%, and 18%, respectively, per 1-mmol/L higher LDL-c, and the risk of CVD mortality was increased by 19% per 1-mmol/L higher LDL-c. Reduced all-cause and non-CVD/noncancer mortality risks were only significant in males but not females (pinteraction < .05).
Conclusions
There were U-shaped relationships between LDL-c and all-cause mortality, cancer mortality, and noncancer/non-CVD mortality in healthy older adults. Higher LDL-c levels were associated with an increased risk of CVD mortality. Future studies are warranted to confirm our results.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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