Influence of acute dietary nitrate supplementation timing on nitrate metabolism, central and peripheral blood pressure and exercise tolerance in young men
Rowland SN, James LJ, O'Donnell E, Bailey SJ
European journal of applied physiology · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- NIHR Leicester Biomedical Research Centre
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-12-02 · Eur J Appl Physiol · vol. 124 · número 5 · págs. 1381–1396
- Editorial
- Springer Science+Business Media
- Citado
- 13 citas · más que el 92% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 92 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention
- Palabras clave
- dietary nitrate, beetroot juice, nitrite, central blood pressure, brachial blood pressure, salivary flow rate, salivary pH, exercise tolerance, time to exhaustion, nitrate metabolism, young men
- MeSH
- saliva, humans, beta vulgaris, nitrates, cross-over studies, blood pressure, exercise tolerance, dietary supplements, adult, male, young adult, fruit and vegetable juices
4 autores
- Samantha N. Rowland🇬🇧Loughborough University
- Lewis John James🇬🇧Loughborough University
- Emma O’Donnell🇬🇧Loughborough University
- Stephen J. Bailey🇬🇧 · autor de correspondenciaLoughborough University; University of Leicester
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Dietary nitrate (NO3-) supplementation can lower systolic blood pressure (SBP) and improve exercise performance. Salivary flow rate (SFR) and pH are key determinants of oral NO3- reduction and purported to peak in the afternoon. We tested the hypotheses that NO3--rich beetroot juice (BR) would increase plasma [nitrite] ([NO2-]), lower SBP and improve exercise performance to a greater extent in the afternoon (AFT) compared to the morning (MORN) and evening (EVE).
Method
Twelve males completed six experimental visits in a repeated-measures, crossover design. NO3--depleted beetroot juice (PL) or BR (~ 13 mmol NO3-) were ingested in the MORN, AFT and EVE. SFR and pH, salivary and plasma [NO3-] and [NO2-], brachial SBP and central SBP were measured pre and post supplementation. A severe-intensity exercise tolerance test was completed to determine cycling time to exhaustion (TTE).
Results
There were no between-condition differences in mean SFR or salivary pH. The elevation in plasma [NO2-] after BR ingestion was not different between BR-MORN, BR-AFT and BR-EVE. Brachial SBP was unchanged following BR supplementation in all conditions. Central SBP was reduced in BR-MORN (- 3 ± 4 mmHg), BR-AFT (- 4 ± 3 mmHg), and BR-EVE (- 2 ± 3 mmHg), with no differences between timepoints. TTE was not different between BR and PL at any timepoint.
Conclusion
Acute BR supplementation was ineffective at improving TTE and brachial SBP and similarly effective at increasing plasma [NO2-] and lowering central SBP across the day, which may have implications for informing NO3- supplementation strategies.
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