Financiado en parte por Alexion Pharmaceuticals, California Walnut Commission, International Nut and Dried Fruit Council
A Walnut-Enriched Diet for 2 Years Changes the Serum Oxylipin Profile in Healthy Older Persons
Cofán M, Checa A, Serra-Mir M, Roth I, Valls-Pedret C, Lopez-Illamola A, Doménech M, Rajaram S, Lázaro I, Sabaté J, Ros E, Wheelock CE, Sala-Vila A
The Journal of nutrition · 4 citas
Etiquetas de revisión
Financiado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Alexion Pharmaceuticals
- Grupo de la industria
- California Walnut Commission
- Grupo de la industria
- International Nut and Dried Fruit Council
Según 3 financiadores declarados.
Publicación
- Publicado
- 2023-12-09 · J Nutr · vol. 154 · número 2 · págs. 395–402
- Editorial
- Elsevier BV
- Citado
- 10 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nuts composition and effects · Edible Oils Quality and Analysis
- Palabras clave
- oxylipins, alpha-linolenic acid, omega-3 fatty acids, dietary intervention, older adults, eicosanoids, dietary adherence, aging, cardiovascular disease, inflammation, healthy aging, dietary fiber intake
- MeSH
- humans, juglans, fatty acids, omega-3, alpha-linolenic acid, fatty acids, unsaturated, diet, aged, aged, 80 and over, female, male, oxylipins
13 autores
- Montserrat Cofán🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Antonio Checa🇸🇪Karolinska Institutet
- Mercè Serra‐Mir🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Irene Roth🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Cinta Valls‐Pedret🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Anna López-Illamola🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Mónica Doménech🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Sujatha Rajaram🇺🇸Loma Linda University
- Iolanda Lázaro🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Del Mar; Hospital del Mar Research Institute
- Joan Sabaté🇺🇸Loma Linda University
- Emilio Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Craig E. Wheelock🇸🇪 · autor de correspondenciaKarolinska University Hospital; Karolinska Institutet
- Aleix Sala‐Vila🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Del Mar; Hospital del Mar Research Institute; Fatty Acid Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oxylipins are products derived from polyunsaturated fatty acids (PUFAs) that play a role in cardiovascular disease and aging. Fish oil-derived n-3 PUFAs promote the formation of anti-inflammatory and vasodilatory oxylipins; however, there are little data on oxylipins derived from α-linolenic acid (C18:3n-3), the primary plant-derived n-3 PUFA. Walnuts are a source of C18:3n-3.
Objectives
To investigate the effect on serum oxylipins of a diet enriched with walnuts at 15% energy (30-60 g/d; 2.6-5.2 g C18:3n-3/d) for 2 y compared to a control diet (abstention from walnuts) in healthy older males and females (63-79 y).
Methods
The red blood cell proportion of α-linolenic acid was determined by gas chromatography as a measure of compliance. Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure serum concentrations of 53 oxylipins in participants randomly assigned to receive the walnut diet (n = 64) or the control diet (n = 51). Two-year concentration changes (final minus baseline) were log-transformed (base log-10) and standardized (mean-centered and divided by the standard deviation of each variable). Volcano plots were then generated (fold change ≥1.5; false discovery rate ≤0.1). For each oxylipin delta surviving multiple testing, we further assessed between-intervention group differences by analysis of covariance adjusting for age, sex, BMI, and the baseline concentration of the oxylipin.
Results
The 2-y change in red blood cell C18:3n-3 in the walnut group was significantly higher than that in the control group (P < 0.001). Compared to the control diet, the walnut diet resulted in statistically significantly greater increases in 3 C18:3n-3-derived oxylipins (9-HOTrE, 13-HOTrE, and 12,13-EpODE) and in the C20:5n-3 derived 14,15-diHETE, and greater reductions of the C20:4n-6-derived 5-HETE, 19-HETE, and 5,6-diHETrE.
Conclusions
Long-term walnut consumption changes the serum oxylipin profile in healthy older persons. Our results add novel mechanistic evidence on the cardioprotective effects of walnuts.
Trial registration
Clinicaltrials.gov Identifier: NCT01634841.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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