Effects of intermittent fasting combined with physical exercise on cardiometabolic outcomes: systematic review and meta-analysis of clinical studies
Kazeminasab F, Baharlooie M, Karimi B, Mokhtari K, Rosenkranz SK, Santos HO
Nutrition reviews · 16 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2023-12-15 · Nutr Rev · vol. 82 · número 12 · págs. 1726–1740
- Editorial
- Oxford University Press
- Citado
- 20 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Cardiovascular and exercise physiology · Physical Activity and Health
- Palabras clave
- intermittent fasting, physical activity, cardiometabolic health, body weight, lipid profile, blood pressure, LDL cholesterol, triglycerides, HDL cholesterol, total cholesterol, obesity
- MeSH
- humans, cardiovascular diseases, obesity, body weight, lipids, triglycerides, exercise, fasting, blood pressure, intermittent fasting
6 autores
- Fatemeh Kazeminasab🇮🇷University of Kashan
- Maryam Baharlooie🇮🇷University of Isfahan
- Bahareh Karimi🇮🇷University of Isfahan
- Khatereh Mokhtari🇮🇷Royan Institute; Academic Center for Education, Culture and Research
- Sara K. Rosenkranz🇺🇸University of Nevada, Las Vegas
- Heitor Oliveira Santos · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Different intermittent fasting (IF) protocols have been proven to be efficient in improving cardiometabolic markers, but further research is needed to examine whether or not combining IF regimens plus physical exercise is superior to control diets (ie, nonfasting eating) plus physical exercise in this setting.
Objective
The aim of this study was to determine whether or not combining IF plus exercise interventions is more favorable than a control diet plus exercise for improving cardiometabolic health outcomes.
Data source
PubMed, Scopus, and Web of Science were comprehensively searched until April 2023.
Data extraction
Electronic databases were searched for clinical trials that determined the effect of IF plus exercise vs a control diet plus exercise on body weight, lipid profile (high-density lipoprotein [HDL], low-density lipoprotein [LDL], triglycerides, and total cholesterol), and systolic and diastolic blood pressure (SBP and DBP, respectively). Analyses were conducted for IF plus exercise vs a nonfasting diet plus exercise to calculate weighted mean differences (WMDs).
Data analysis
The meta-analysis included a total of 14 studies, with a total sample of 360 adults with or without obesity. The duration ranged from 4 to 52 weeks. IF plus exercise decreased body weight (WMD = -1.83 kg; P = 0.001), LDL (WMD = -5.35 mg/dL; P = 0.03), and SBP (WMD = -2.99 mm Hg; P = 0.003) significantly more than a control diet plus exercise. HDL (WMD = 1.57 mg/dL; P = 0.4) and total cholesterol (WMD = -2.24 mg/dL; P = 0.3) did not change significantly for IF plus exercise vs a control diet plus exercise, but there was a trend for reducing triglycerides (WMD = -13.13 mg/dL; P = 0.07) and DBP (WMD = 2.13 mm Hg; P = 0.05), which shows clinical magnitude.
Conclusion
IF plus exercise improved some cardiometabolic outcomes (body weight, blood pressure, and lipid profile) compared with a control diet plus exercise.
Systematic review registration
PROSPERO registration no. CRD42023423878.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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