Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk
Stern MC, Sanchez Mendez J, Kim AE, Obón-Santacana M, Moratalla-Navarro F, Martín V, Moreno V, Lin Y, Bien SA, Qu C, Su YR, White E, Harrison TA, Huyghe JR, Tangen CM, Newcomb PA, Phipps AI, Thomas CE, Kawaguchi ES, Lewinger JP, Morrison JL, Conti DV, Wang J, Thomas DC, Platz EA, Visvanathan K, Keku TO, Newton CC, Um CY, Kundaje A, Shcherbina A, Murphy N, Gunter MJ, Dimou N, Papadimitriou N, Bézieau S, van Duijnhoven FJB, Männistö S, Rennert G, Wolk A, Hoffmeister M, Brenner H, Chang-Claude J, Tian Y, Le Marchand L, Cotterchio M, Tsilidis KK, Bishop DT, Melaku YA, Lynch BM, Buchanan DD, Ulrich CM, Ose J, Peoples AR, Pellatt AJ, Li L, Devall MAM, Campbell PT, Albanes D, Weinstein SJ, Berndt SI, Gruber SB, Ruiz-Narvaez E, Song M, Joshi AD, Drew DA, Petrick JL, Chan AT, Giannakis M, Peters U, Hsu L, Gauderman WJ
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 17 citas
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Según 66 financiadores declarados.
Publicación
- Publicado
- 2023-12-19 · Cancer Epidemiol Biomarkers Prev · vol. 33 · número 3 · págs. 400–410
- Editorial
- American Association for Cancer Research
- Citado
- 19 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nutritional Studies and Diet · Genetic Associations and Epidemiology · Meat and Animal Product Quality
- Palabras clave
- Red meat, Colorectal cancer, Processed meat, Confidence interval, Medicine, Genome-wide association study, Genotyping, Quartile, Single-nucleotide polymorphism, Internal medicine, Cancer, Genetics, Biology, Genotype, Food science, Gene, Pathology
- MeSH
- humans, colorectal neoplasms, risk factors, meat, gene-environment interaction, red meat
72 autores
- Mariana Carla Stern🇺🇸 · autor de correspondenciaUniversity of Southern California; USC Norris Comprehensive Cancer Center
- Joel Sanchez Mendez🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Andre E. Kim🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Mireia Obón‐Santacana🇪🇸Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Ferrán Moratalla-Navarro🇪🇸Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universitat de Barcelona
- Vicente Martín🇪🇸Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universidad de León
- Vı́ctor Moreno🇪🇸Bellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Universitat de Barcelona
- Yi Lin🇺🇸Fred Hutch Cancer Center
- Stephanie A. Bien🇺🇸Fred Hutch Cancer Center
- Conghui Qu🇺🇸Fred Hutch Cancer Center
- Yu‐Ru Su🇺🇸Fred Hutch Cancer Center
- Emily White🇺🇸University of Washington; Fred Hutch Cancer Center
- Tabitha A. Harrison🇺🇸Fred Hutch Cancer Center
- Jeroen R. Huyghe🇺🇸Fred Hutch Cancer Center
- Catherine M. Tangen🇺🇸Fred Hutch Cancer Center
- Polly A. Newcomb🇺🇸University of Washington; Fred Hutch Cancer Center
- Amanda I. Phipps🇺🇸University of Washington; Fred Hutch Cancer Center
- Claire Elizabeth Thomas🇺🇸Fred Hutch Cancer Center
- Eric S. Kawaguchi🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Juan Pablo Lewinger🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- John L. Morrison🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- David V. Conti🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Jun Wang🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Duncan Campbell Thomas🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
- Elizabeth A. Platz🇺🇸Johns Hopkins University
- Kala Visvanathan🇺🇸Johns Hopkins University
- Temitope O. Keku🇺🇸University of North Carolina at Chapel Hill
- Christina C. Newton🇺🇸American Cancer Society
- Caroline Y. Um🇺🇸American Cancer Society
- Anshul Kundaje🇺🇸Stanford University
- Anna Shcherbina🇺🇸Stanford University
- Neil Murphy🇫🇷Centre international de recherche sur le cancer
- Marc James Gunter🇫🇷🇬🇧Centre international de recherche sur le cancer; Imperial College London
- Niki L. Dimou🇫🇷Centre international de recherche sur le cancer
- Nikos Papadimitriou🇫🇷Centre international de recherche sur le cancer
- Stéphane Bezieau🇫🇷Centre Hospitalier Universitaire de Nantes
- Fränzel J.B. van Duijnhoven🇳🇱Wageningen University & Research
- Satu Männistö🇫🇮Finnish Institute for Health and Welfare
- Gad Rennert🇮🇱Technion – Israel Institute of Technology; Carmel Medical Center; Rappaport Family Institute for Research in the Medical Sciences; Clalit Health Services
- Alicja Wolk🇸🇪Karolinska Institutet
- Michael Hoffmeister🇩🇪German Cancer Research Center; Heidelberg University
- Hermann Brenner🇩🇪German Cancer Research Center; Heidelberg University; National Center for Tumor Diseases
- Jenny C. Chang-Claude🇩🇪Universität Hamburg; German Cancer Research Center; Heidelberg University; University Medical Center Hamburg-Eppendorf; University Cancer Center Hamburg
- Yu Tian🇩🇪🇨🇳German Cancer Research Center; Capital Medical University; Heidelberg University
- Loı̈c Le Marchand🇺🇸Cancer Center of Hawaii
- Michelle Cotterchio🇨🇦Cancer Care Ontario
- Konstantinos K. Tsilidis🇬🇧Imperial College London
- D. Timothy Bishop🇬🇧University of Leeds
- Yohannes Adama Melaku🇦🇺Cancer Council Victoria; Adelaide Institute for Sleep Health
- Brigid Mary Lynch🇦🇺The University of Melbourne; Cancer Council Victoria
- Daniel D. Buchanan🇦🇺The Royal Melbourne Hospital; The University of Melbourne; Victorian Comprehensive Cancer Centre
- Cornelia M. Ulrich🇺🇸University of Utah; Huntsman Cancer Institute; Utah Department of Health; University of Utah Health Care
- Jennifer Ose🇺🇸University of Utah; Huntsman Cancer Institute; Utah Department of Health; University of Utah Health Care
- Anita Roselyn Peoples🇺🇸University of Utah; Huntsman Cancer Institute; Utah Department of Health; University of Utah Health Care
- Andrew Jared Pellatt🇺🇸The University of Texas MD Anderson Cancer Center
- Li Li🇺🇸University of Virginia
- Matthew A.M. Devall🇺🇸University of Virginia
- Peter T. Campbell🇺🇸Albert Einstein College of Medicine
- Demetrius Albanes🇺🇸Center for Cancer Research
- Stephanie J. Weinstein🇺🇸Center for Cancer Research
- Sonja I. Berndt🇺🇸Center for Cancer Research
- Stephen B. Gruber🇺🇸City Of Hope National Medical Center
- Edward Ruiz-Narváez🇺🇸University of Michigan
- Mingyang Song🇺🇸Harvard University; Massachusetts General Hospital
- Amit D. Joshi🇺🇸Harvard University; Massachusetts General Hospital
- David A. Drew🇺🇸Massachusetts General Hospital
- Jessica L. Petrick🇺🇸Boston University
- Andrew Tan Chan🇺🇸Broad Institute; Brigham and Women's Hospital; Harvard University; Massachusetts General Hospital
- Marios Giannakis🇺🇸Broad Institute; Dana-Farber Cancer Institute; Dana-Farber/Harvard Cancer Center
- Ulrike Peters🇺🇸 · autor de correspondenciaUniversity of Washington; Fred Hutch Cancer Center
- Li Hsu🇺🇸University of Washington; Fred Hutch Cancer Center; Cancer Research And Biostatistics
- W. James Gauderman🇺🇸 · autor de correspondenciaUniversity of Southern California; USC Norris Comprehensive Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
High red meat and/or processed meat consumption are established colorectal cancer risk factors. We conducted a genome-wide gene-environment (GxE) interaction analysis to identify genetic variants that may modify these associations.
Methods
A pooled sample of 29,842 colorectal cancer cases and 39,635 controls of European ancestry from 27 studies were included. Quantiles for red meat and processed meat intake were constructed from harmonized questionnaire data. Genotyping arrays were imputed to the Haplotype Reference Consortium. Two-step EDGE and joint tests of GxE interaction were utilized in our genome-wide scan.
Results
Meta-analyses confirmed positive associations between increased consumption of red meat and processed meat with colorectal cancer risk [per quartile red meat OR = 1.30; 95% confidence interval (CI) = 1.21-1.41; processed meat OR = 1.40; 95% CI = 1.20-1.63]. Two significant genome-wide GxE interactions for red meat consumption were found. Joint GxE tests revealed the rs4871179 SNP in chromosome 8 (downstream of HAS2); greater than median of consumption ORs = 1.38 (95% CI = 1.29-1.46), 1.20 (95% CI = 1.12-1.27), and 1.07 (95% CI = 0.95-1.19) for CC, CG, and GG, respectively. The two-step EDGE method identified the rs35352860 SNP in chromosome 18 (SMAD7 intron); greater than median of consumption ORs = 1.18 (95% CI = 1.11-1.24), 1.35 (95% CI = 1.26-1.44), and 1.46 (95% CI = 1.26-1.69) for CC, CT, and TT, respectively.
Conclusions
We propose two novel biomarkers that support the role of meat consumption with an increased risk of colorectal cancer.
Impact
The reported GxE interactions may explain the increased risk of colorectal cancer in certain population subgroups.
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