Financiado en parte por Sanofi, Regeneron Pharmaceuticals, Aimmune Therapeutics, Allergy Therapeutics
Partial Egg Consumption Modifies the Diagnostic Performance of Allergy Tests to Predict Outcome of Double-Blind Placebo-Controlled Food Challenges to Egg
Marques-Mejias A, Radulovic S, Foong RX, Bartha I, Krawiec M, Kwok M, Jama Z, Harrison F, Ricci C, Lack G, Du Toit G, Santos AF
The journal of allergy and clinical immunology. In practice · 8 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Sanofi
- Empresa
- Regeneron Pharmaceuticals
- Organización sin fines de lucro
- Immune Tolerance Network
- Empresa
- Aimmune Therapeutics
- Empresa
- Allergy Therapeutics
- Organización sin fines de lucro
- Action Medical Research
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- Asthma and Lung UK
- Universidad u hospital
- King's College London
- Organización sin fines de lucro
- Rosetrees Trust
- Gobierno
- National Institutes of Health
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Medical Research Council
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Subvenciones
- Medical Research Council (MR/T032081/1); Asthma and Lung UK (AUK‐BC‐2015‐01); Medical Research Council (MR/M008517/1); Biotechnology and Biological Sciences Research Council (M008517); Medical Research Council (MR/M008517/1); Medical Research Council (MC_PC_18052); Medical Research Council (MR/T032081/1); Medical Research Council (MC_PC_18052)
Según 15 financiadores declarados.
Publicación
- Publicado
- 2023-12-27 · J Allergy Clin Immunol Pract · vol. 12 · número 3 · págs. 660–669.e5
- Editorial
- Elsevier BV
- Citado
- 8 citas · más que el 78% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 21 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Food Allergy and Anaphylaxis Research · Asthma and respiratory diseases · Consumer Attitudes and Food Labeling
- Palabras clave
- Medicine, Egg allergy, Placebo, Double blind, Allergy, Food allergy, Consumption (sociology), Immunology, Pathology, Alternative medicine
- MeSH
- humans, egg hypersensitivity, immunoglobulin e, immunoglobulin g, ovomucin, allergens, skin tests, eggs, egg white, child
12 autores
- Andreina Marques‐Mejias🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- Suzana Radulović🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- Ru‐Xin Foong🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- Irene Bartha🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- Marta Krawiec🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- Matthew Kwok🇬🇧King's College London; King's College School
- Zainab Jama🇬🇧King's College London; King's College School
- Faye Harrison🇬🇧King's College London; King's College School
- Hannah Ricci🇿🇦North-West University
- Gideon Lack🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- George Du Toit🇬🇧St Thomas' Hospital; Evelina London Children's Healthcare
- Alexandra F. Santos🇬🇧 · autor de correspondenciaSt Thomas' Hospital; Evelina London Children's Healthcare
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Many children are consuming some egg when they are diagnosed with egg allergy. We hypothesized that egg consumption could modify the diagnostic performance of allergy tests.
Objective
To stratify diagnostic performance of tests according to egg consumption status.
Methods
The BAT2 study (NCT03309488) participants underwent oral food challenge (OFC), food-frequency questionnaires, skin prick test (SPT), specific immunoglobulin E (sIgE) and specific immunoglobulin G4 (sIgG4) and basophil activation test (BAT).
Results
At study entry, 45% of participants reported partial egg consumption ("consumers") and 55% were avoiding egg strictly ("avoiders"). Avoiders had larger SPT (P < .001), higher BAT to egg (P < .001), sIgE to egg white (EW; P = .001) and to ovalbumin (OVA; P = .001), but not to ovomucoid (P = .231). Consumers had higher levels of sIgG4 to all egg allergens (P < .001) than avoiders. In consumers, the test with the best diagnostic performance was BAT (area under the curve [AUC] = .912) followed by SPT to raw egg (AUC = 0.805), EW-sIgE (AUC = 0.738), and OVA-sIgE (AUC = 0.732). In avoiders, the best tests were BAT (AUC = 0.834) and EW-sIgE (AUC = 0.833) followed by OVA-sIgE (AUC = 0.793) and SPT to EW (AUC=0.789). Using 100% sensitivity and 100% specificity cut-offs, the proportion of patients requiring OFC were 33% for BAT, 53% for SPT to raw egg, 61% for OVA-sIgE, and 73% for EW-sIgE for consumers; and 73% for BAT, 79% for EW-sIgE, and 93% for SPT to EW for avoiders.
Conclusions
The diagnostic performance of tests is influenced by the immunomodulatory effect of egg consumption. BAT is the most reliable test and reduced the need for OFC, particularly in partial egg consumers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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