Dietary nitrate supplementation to enhance exercise capacity in patients with COPD: Evidence from a meta-analysis of randomized controlled trials and a network pharmacological analysis
Wang J, Feng F, Zhao Y, Bai L, Xu Y, Wei Y, He H, Zhou X
Respiratory medicine · 3 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Postgraduate Research and Practice Innovation Program of Jiangsu Province
- Subvenciones
- National Natural Science Foundation of China (82004307)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2023-12-28 · Respir Med · vol. 222 · pág. 107498
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 42% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Asthma and respiratory diseases · Nitric Oxide and Endothelin Effects
- Palabras clave
- nitrate supplementation, chronic obstructive pulmonary disease, exercise capacity, endothelial function, dyspnea, exhaled nitric oxide, AKT1, IL1B, ERK1, caspase-3, network pharmacology
- MeSH
- humans, pulmonary disease, chronic obstructive, nitrates, exercise tolerance, quality of life, dietary supplements, caspase 3, randomized controlled trials as topic
8 autores
- Jing Wang🇨🇳Nanjing University of Chinese Medicine
- Fanchao Feng🇨🇳Nanjing University of Chinese Medicine
- Yang Zhao🇨🇳Nanjing University of Chinese Medicine
- Le Bai🇨🇳Nanjing University of Chinese Medicine
- Yong Xu🇨🇳Nanjing University of Chinese Medicine
- Yun Wei🇨🇳Nanjing University of Chinese Medicine
- Hailang He🇨🇳 · autor de correspondenciaNanjing University of Chinese Medicine
- Xianmei Zhou🇨🇳 · autor de correspondenciaNanjing University of Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The potential effects of nitrate in patients with chronic obstructive pulmonary disease (COPD) have attracted increased research interest. However, previous clinical trials have reported inconsistent results, and consecutive meta-analyses have failed to reach a consensus. Since some randomized controlled trials have recently been conducted that can provide more evidence, we performed an updated meta-analysis.
Methods
A comprehensive literature search was conducted using PubMed, the Cochrane Library, Embase, and Web of Science databases to identify trials that assessed the efficacy and safety of nitrate in patients with COPD. The Revman 5.3 software was used for data analysis. Mean difference (MD) or standardized mean difference (SMD) with 95 % confidence interval (CI) was used as the effect measure, and forest plots were used to display individual and pooled results. Network pharmacology analysis was conducted to investigate the potential mechanisms of nitrate action in COPD.
Results
Eleven studies involving 287 patients were included in this meta-analysis. The results indicated that dietary nitrate supplementation increased plasma nitrate and nitrite concentrations and fractional exhaled nitric oxide in patients with COPD. Nitrate improved exercise capacity [SMD = 0.38, 95 % CI = 0.04-0.72] and endothelial function [MD = 9.41, 95 % CI = 5.30-13.52], and relieved dyspnea in patients with COPD. Network pharmacology identified AKT1, IL1B, MAPK3, and CASP3 as key treatment targets.
Conclusion
Dietary nitrate supplementation could be used as a potential treatment for patients with COPD, especially to increase their exercise capacity. The underlying mechanisms may be related to AKT1, IL1B, MAPK3, and CASP3.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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