Improvements in markers of inflammation and coagulation potential following a 5-day high-fat diet rich in cottonseed oil vs. Olive oil in healthy males
Catherine Prater M, Polley KR, Cooper JA
Cytokine · 2 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-01-03 · Cytokine · vol. 175 · pág. 156494
- Editorial
- Elsevier BV
- Citado
- 3 citas · más que el 66% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 72 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- cottonseed oil, olive oil, high-fat diet, omega-6 fatty acids, low-grade inflammation, coagulation potential, TNF-α, tissue factor, interleukin-6, C-reactive protein, plasminogen activator inhibitor-1, healthy men
- MeSH
- humans, chronic disease, inflammation, cottonseed oil, tumor necrosis factor-alpha, plasminogen activator inhibitor 1, interleukin-6, diet, male, young adult, diet, high-fat, olive oil
3 autores
- Mary Catherine Prater🇺🇸University of Georgia
- Kristine R. Polley🇺🇸University of Georgia
- Jamie A. Cooper🇺🇸 · autor de correspondenciaUniversity of Georgia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Low-grade inflammation is believed to be a risk factor for chronic diseases and is nutritionally responsive. Cottonseed oil (CSO), which is rich in n-6 polyunsaturated fats, has been shown to lower cholesterol and other chronic disease risk factors. The purpose of this secondary analysis was to determine the comparative responses of markers of inflammation and coagulation potential of healthy adult males consuming diets rich in CSO vs. olive oil (OO).
Methods
Fifteen normal-weight males, ages 21.7 ± 2.58y, completed a randomized crossover trial. Each intervention consisted of a 3-day lead-in diet and a 5-day outpatient, controlled feeding intervention (CSO or OO). There was a 2 to 4-week washout period between interventions. The 5-day intervention diets were 35 % carbohydrate, 15 % protein, and 50 % fat, enriched with either CSO or OO (44 % of total energy from oil). At pre- and post- diet intervention visits, a fasting blood draw was collected for analysis of markers of inflammation (Tumor Necrosis Factor Alpha (TNF-α), Interleukin-6 (IL-6), C-Reactive Protein (CRP)) and coagulation potential (Tissue Factor (TF), Plasminogen Activator Inhibitor-1 (PAI-1)).
Results
The CSO-enriched diets reduced TNF-α (CSO: -0.12 ± 0.02 pg/ml, OO: -0.01 ± 0.05 pg/ml; p < 0.01) and TF (CSO: -0.59 ± 0.68 pg/ml, OO: 1.13 ± 0.83 pg/ml; p = 0.02) compared to OO diets. There were no differences in IL-6, CRP, or PAI-1 between diets.
Conclusion
A 5-day, CSO-enriched diet may be sufficient to reduce inflammation and coagulation potential compared to OO-enriched diets in a healthy male population which could have implications in chronic disease prevention.
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